Genotoxic and mutagenic evaluation of the protective effect of exogenous melatonin in adult rats and their offspring exposed to the insecticides methomyl and cypermethrin during pregnancy

Publication date: Available online 19 October 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Ketsia Sabrina do Nascimento Marinho, Clovis José Cavalcanti Lapa Neto, Ilka Dayane Duarte de Sousa Coelho, Meykson Alexandre da Silva, Maria Eduarda Gomes Melo, Katharine Raquel Pereira dos Santos, Cristiano Aparecido Chagas, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley TeixeiraAbstractExposure of pregnant women to pesticides in an occupational or incidental manner has been pointed out as a possible cause of health problems in newborns. Cypermethrin and methomyl are insecticides whose active compounds and metabolites can cause harm to the health of pregnant women and their offspring. Both contribute to increases in the concentrations of oxidizing agents that damage DNA, causing mutations. Thus, the use of antioxidant substances, such as melatonin, could serve as protection against genetic damage, reducing the problems caused by insecticides. Here, we evaluated the protective effect of exogenous melatonin in adult rats and their offspring exposed to methomyl and cypermethrin during the gestational period. Thirty adult rats were divided into five groups from the first day of pregnancy: NC - negative control, Mth received 0.02 mg/kg/day of methomyl, Cyp received 0.05 mg/kg/day cypermethrin, MthMl received 0.02 mg/kg/day methomyl combined with 10 mg/kg/day melatonin, and CypMl received 0.05&thi...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research

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Contributors : Saniya Rattan ; Hannah K Beers ; Athilakshmi Kannan ; Anujaianthi Ramakrishnan ; Emily Brehm ; Indrani Bagchi ; Joseph M Irudayaraj ; Jodi A Flaws ; Mary J LawsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDi(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer and known endocrine disrupting chemical, which causes transgenerational reproductive toxicity in female rodents. However, the mechanisms of action underlying the transgenerational toxicity of DEHP are not understood. Therefore, this study determined the effects of prenatal and ancestral DEHP exposure o...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Publication date: Available online 21 September 2020Source: Pregnancy HypertensionAuthor(s): Karen Jiménez, Adrien Morel, Laura Parada-Niño, María Alejandra González-Rodriguez, Stephanie Flórez, David Bolívar-Salazar, Silvia Becerra-Barona, Angel Aguirre-García, Tatiana Murcia, Luisa Fernanda Castillo, Carolina Carlosama, Javier Ardila, Daniel Vaiman, Norma Serrano, Paul Laissue
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
SUMMARY Since the outbreak of a cluster of patients with pneumonia of unknown cause in Wuhan, Hubei Province, China, in December 2019, the disease was later officially named coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), quickly spreading globally. Pregnant women and children are particularly vulnerable during disasters and emergencies. Comprehensive and applicable emergency preparedness and response are definitely important methods to prevent and contain the COVID-19 pandemic. The rational allocation of pharmaceutical resources plays an important role in...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
CONCLUSION Further studies with a great number of cases are warranted to elucidate whether the virus may be vertically transmitted to the fetus and if any maternal conditions can influence that. Our findings seem to demonstrate that vertical transmission is possible but quite unusual.RESUMO OBJETIVO Revisar as evid ências científicas atuais sobre a transmissão vertical relacionada à infecção pelo novo coronavírus 2019 (COVID-19). MÉTODOS Uma revisão integrativa foi realizada por dois pesquisadores independentes, com base na literatura disponível nas bases...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
Publication date: October 2020Source: Canadian Journal of Diabetes, Volume 44, Issue 7Author(s): Taylor S. Morriseau, Brandy A. Wicklow, Barry Lavallee
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
Today's open access paper discusses the impact of mitochondrial DNA damage on female reproductive capabilities. Mitochondria are the power plants of the cell, a herd of hundreds of organelles responsible for packaging the chemical energy store molecule ATP, used to power cellular processes. They are additionally deeply integrated into many core cellular processes. Mitochondria are the evolved descendants of ancient symbiotic bacteria: they carry their own small genome, the mitochondrial DNA, and replicate like bacteria. Unfortunately this mitochondrial DNA is more vulnerable and less proficiently repaired than the nuclear ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
By Mabingue Ngom and Shoko ArakakiNEW YORK, Sep 21 2020 (IPS) The countries of Central Sahel—Burkina Faso, Mali, and Niger—face an unprecedented crisis, marked by violent extremism, forced displacement, and rising insecurity. The sharp increase in armed attacks on communities, health centres, schools and other public institutions and infrastructure has disrupted livelihoods and access to social services. The impact on affected people is devastating. As the international community responds to the crisis, we must meet immediate needs, and invest in long-term development. We must also work on shaping peace togeth...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Armed Conflicts Crime & Justice Development & Aid Economy & Trade Education Gender Gender Violence Headlines Health Human Rights Humanitarian Emergencies Inequity Peace Sustainability TerraViva United Nations Source Type: news
[Daily News] BREASTFEEDING mothers have been encouraged to make sure that they should not feed their children, who are less than six months with solid foodstuffs that subject them to digestion problems.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
Over the past few months, we have all seen the results of significant disruption to daily life due to the COVID-19 pandemic, high levels of unemployment, and civil unrest driven by chronic racial injustice. These overlapping waves of societal insult have begun to bring necessary attention to the importance of health care disparities in the United States. Direct links between stress, discrimination, racial injustice, and health outcomes occurring over one’s lifespan have not been well studied. But a recently published article in the journal Hypertension has looked at the connection between discrimination and increased...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health care disparities Hypertension and Stroke Source Type: blogs
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