Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation.
CONCLUSION: Collectively, these findings suggest that the increased ventricular arrhythmia susceptibility of type 2 diabetic mouse hearts is due to dysregulation of the sympathetic ventricular control. PMID: 31625779 [PubMed - as supplied by publisher]
Several omics platforms currently are being used for biomarker discovery. Data integration from multiple platforms while simultaneously accounting for clinical variables is only beginning to be attempted. Kammer and colleagues were interested in identifying prognostic biomarkers for rapid progression of chronic kidney disease (CKD) in patients with type 2 diabetes. They used a novel Bayesian approach to analyze clinical, proteomic, metabolomic, and lipidomic data from patients whose CKD progressed rapidly or remained stable.
As many as 10% to 20% of patients undergoing kidney transplantation develop post-transplant diabetes mellitus, which is associated with increased mortality. Even borderline changes in glucose metabolism, so-called prediabetes, may involve a similar risk. A recent study by Porrini et al. showed for the first time that such changes in glucose metabolism are in fact associated with future cardiovascular disease and death in kidney-transplanted patients. This commentary discusses the relevance and clinical implications of these new findings.
Authors: Coperchini F, Croce L, Denegri M, Awwad O, Ngnitejeu ST, Magri F, Chiovato L, Rotondi M Abstract Phenformin is a biguanide drug which, besides the original anti-diabetic effect, also exerts anti-cancer effects. The aim of this study was to further characterize these latter in terms of both cell-viability and modulation of the secretion of the pro-tumorigenic chemokine CXCL8. Normal human thyrocytes in primary cultures (NHT) and thyroid cancer cell lines, TPC-1 and 8505C (RET/PTC and BRAFV600E mutated, respectively) were treated with increasing concentrations of phenformin at different times. Cell-viability...
Authors: Geagea AG, Rizzo M, Jurjus A, Cappello F, Leone A, Tomasello G, Gracia C, Kattar SA, Massaad-Massade L, Eid A Abstract [This corrects the article DOI: 10.18632/oncotarget.26641.]. PMID: 31741717 [PubMed - in process]
Conclusion: An unusual familial cone-rod dystrophy phenotype was associated with heterozygous CRX deletion, a pathogenic variant that had a presumed mechanism of haploinsufficiency. The consistent finding of arcuate temporal macular lesions among affected family members was striking, particularly given the variable expressivity previously associated with CRX-related retinopathy. Additional phenotypic studies are needed to assess how frequently this temporal arcuate retinopathy appearance occurs in individuals harboring a similar deletion who are not from the current family. PMID: 31743059 [PubMed - as supplied by publisher]
Publication date: Available online 19 November 2019Source: Journal of Functional FoodsAuthor(s): Lucía Diez-Gutiérrez, Leire San Vicente, Luis Javier R. Barrón, María del Carmen Villarán, María ChávarriAbstractProbiotics have attracted growing interest in recent decades due to their multiple health benefits. The synergistic relationship between probiotics and prebiotics can enhance the production of metabolites called postbiotics, which are gaining increasing importance because of their beneficial functions in the gastrointestinal tract and their influence on different organ...
Conclusions: The core-competence system framework includes six core competencies, which represent the main characteristics of primary nurse specialists in diabetes care who are highly recommended by experts. It is important to keep in mind that this is only a theoretical framework and thus must be further tested in clinical practice settings in China.
Conclusions: Even though a rare condition, the prevalence is disproportionally frequent in certain ethnic groups and in certain regions; thus, we report our experience of OPMD patients in Southern California.
Conclusions: These results expand the spectrum of mutations in CYP4V2, and suggest that mutations in CYP4V2 may be common in the Chinese population. The phenotype of patients with the homozygous mutation (hom.c.802-8_810del17insGC) is highly heterogeneous. PMID: 31741654 [PubMed - in process]
Condition: Type2 Diabetes Interventions: Drug: Evogliptin 5mg; Drug: Evogliptin Placebo; Drug: Dapagliflozin 10mg; Drug: Metformin ≥ 1000mg Sponsor: Dong-A ST Co., Ltd. Not yet recruiting