Area Deprivation as a Risk Factor for Methicillin-resistant Staphylococcus aureus Infection in Pediatric Cystic Fibrosis

Background: In US cystic fibrosis (CF) patients, methicillin-resistant Staphylococcus aureus (MRSA) rates have tripled in the past 2 decades. Known clinical risk factors include exposure to a healthcare setting, Pseudomonas aeruginosa and CF-related diabetes. Area-level socio-environmental exposures have not been evaluated. We explored the association of area-level deprivation with MRSA prevalence in a pediatric CF Center in the Southeastern United States. Methods: Patients’ residential addresses were geocoded and linked to a composite Area Deprivation Index and Rural-Urban Commuting Area scores. The association of MRSA with Area Deprivation Index and Rural-Urban Commuting Area scores was evaluated using logistic regression with robust standard errors adjusted for sociodemographic covariates (age, sex, race, mother’s and father’s education and household income), clinical risk factors (P. aeruginosa, CF-related diabetes, hospitalizations and number of clinic visits) and clustering. Results: The study included all pediatric patients (N = 231; mean age 12) at a single CF Center. MRSA was present in 44% of subjects. Higher area-level deprivation was correlated with rural residence, lack of parental college education and lower household income (P
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research

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Conclusion: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. PMID: 31730677 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
CONCLUSIONS: Because of its pleiotropic roles in several reproductive events and its association with some life-threatening pathological conditions of pregnancy, bikunin may represent a non-invasive marker for improving follow-up and early diagnosis. Studies showing its usefulness as a drug for reducing the risk of preterm delivery and improving neonatal outcomes have yielded interesting results that deserve to be investigated through further research. PMID: 31728877 [PubMed - as supplied by publisher]
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
The president made an unannounced stop at Walter Reed Army Hospital to have portions of his physical done before his 2020 schedule fills up
Source: Health News: - Category: Consumer Health News Source Type: news
Democrat John Bel Edwards won the race for Louisiana Governor, beating back a Republican challenger who wanted to curtail Medicaid health coverage.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
ConclusionsTaken together, these results illustrate a new model in which Purβ functions to regulate the glucagon/ADCY6/cAMP/PKA/CREB signaling pathway to help maintain glucose homeostasis.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
ConclusionsThe use of the tesaglitazar-[F7, P34]-NPY conjugate is a promising strategy to make use of the beneficial PPARα/γ effects in adipocytes while potentially omitting adverse-effects in other tissues.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
We describe medical evacuations analyzed from the US Air Force Transportation Command Regulating and Command &Control Evacuation System (TRAC2ES).MethodsWe performed a retrospective review of all TRAC2ES medical records for medical evacuations from the AFRICOM theater of operations conducted between January 1, 2008 and December 31, 2018. We abstracted free text data entry in TRAC2ES for diagnostic and therapeutic interventions performed prior to the patient movement request.ResultsDuring this time, there were 963 cases recorded in TRAC2ES originating within AFRICOM. 961 records were complete for analysis. Most patients...
Source: African Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
Publication date: Available online 15 November 2019Source: International Journal of PharmaceuticsAuthor(s): Prabhjot Kaur, Vijay Singh Gondil, Sanjay ChhibberAbstractThe emergence of antibiotic-resistant pathogens has made the treatment of infected burn wounds even more problematical than the pre-antibiotic era. Phage therapy is now being considered a promising treatment options to fight against antibiotic resistant pathogens. Hence, we introduce a novel PVA-SA hydrogel based wound dressing system for topical delivery of bacteriophages and antibiotic to treat infected burn injuries. Hydrogel membrane provides wound healing...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Purpose of review: Methicillin-resistant Staphylococcus aureus (MRSA) remains prevalent in people with cystic fibrosis (CF). As chronic infection is often associated with worse pulmonary outcomes, the organism is concerning to CF providers and patients. This review describes current epidemiology, our understanding of risk factors for MRSA infection, and relevant aspects of treatment with review of new and ongoing trials. Recent findings: Prevalence ranges from a low of 3 to 4% in some European countries to a high of approximately 26% in the United States. Risk factors for chronic MRSA infection include patient-specific fa...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: CYSTIC FIBROSIS: Edited by Nicholas Simmonds and Harry G.M. Heijerman Source Type: research
ConclusionsCFTR mutation is an important factor influencing the cost of CF care. Costs differ among cohorts of CF patients eligible to access new and emergingCFTR repair therapies. These findings support the evaluation of outcome-associated cost inCFTR mutation-specific CF patient groups.
Source: PharmacoEconomics - Category: Health Management Source Type: research
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