Histopathology of catastrophic antiphospholipid syndrome ‐associated nephropathy in a SLE patient without concurrent lupus nephritis

AbstractA 35 ‐year‐old African American male with a history of seizures, presented with nausea, vomiting, abdominal pain, thrombocytopenia (platelet count of 48,000) and acute renal failure (BUN/creatinine – 30/5.6). Urinalysis showed mild proteinuria and microscopic hematuria. He was diagnosed with syste mic lupus erythematosus (SLE) on the basis of positive ANA, anti‐dsDNA, arthritis, thrombocytopenia and hypocomplementemia fulfilling 5 of 11 SLE criteria (1). He also was positive for antibodies to cardiolipin, beta2‐glycoprotein‐I and lupus anticoagulant. ADAMTS13 level was lower than norma l but not indicative of TTP.

Source: Arthritis and Rheumatology - October 13, 2019 Category: Rheumatology Authors: Rajib K Gupta, Eric Liu, Eduardo Bonilla, Hind Elsaid Tags: CLINICAL IMAGE Source Type: research