Association of antidepressants with recurrent, injurious and unexplained falls is not explained by reduced gait speed

Prescription of antidepressants is common among older adults, not just in the treatment of depression but also anxiety, panic disorder, neuropathic pain and urinary incontinence.1 Based on a Eurobarometer survey carried out in 27 European countries, 9.5% of adults aged 55 and over reported antidepressant use in the past year2 while Mars et al3 showed that antidepressant prescribing in the UK increased between 1995 and 2011, particularly in adults aged 46 and over. In older adults, antidepressant use has been associated with an increased likelihood of adverse outcomes such as cardiovascular events, hyponatremia, falls and fractures possibly due to an increase in co-morbidities, polypharmacy and age-related pharmacokinetic and pharmacodynamic changes.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research

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Conclusion: Anal dilatation did not appear to alter anal distensibility in patients with a normal anal function before the STARR procedure. PMID: 31738687 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
Authors: Van Slambrouck J, Vlasselaers J, Devos B Abstract Peritoneal tuberculosis is a rare extrapulmonary manifestation of tuberculosis. Considering the diagnosis of peritoneal tuberculosis in a low prevalence setting can be vital for the further clinical management in selected patients.In a young male with migration background, presenting with generalised abdominal pain, computed tomography revealed ascites, omental and peritoneal thickening and enlarged mesentery lymph nodes. Computed tomography also revealed a distal ureteral calculus at the right vesico-ureteral junction. Diagnostic laparoscopy showed a nodul...
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
Publication date: Available online 18 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Z Malihi, Z Wu, CMM Lawes, J Sluyter, D Waayer, L Toop, K-T Khaw, CA Camargo, R ScraggABSTRACTWith increasing numbers of randomized controlled trials (RCTs) investigating potential health events of vitamin D supplementation, a better understanding is required of the risk factors for adverse events and for study withdrawals. This analysis aimed to identify baseline risk factors of reporting an adverse event in a multi-year randomized double-blinded placebo-controlled trial of vitamin D supplementati...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 18 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Hongwei Liu, Junfeng Liu, Xianfeng Xie, Xuebin LiAbstractThough anesthetic drug delivery system and drug vehicles is generally applied for pain relief, there are have many difficulties and issues due to its short duration carrier and low biocompatibility, effectiveness at the conditions of inflammation at acidic pH. To resolve this issue, we have designed and developed the dual (pH and temperature) responsive bio-nanomaterial to improve the efficiency anesthetic drug delivery system. Chitosan is a uniq...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
ConclusionsThe presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients ’ HRQoL.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionsThese results suggest that O/P ratio can be related to current and future engagement in pro-environmental behavior and improvement in subjective well-being which could lead to an environmentally sustainable society with enhanced quality of life.
Source: Quality of Life Research - Category: Health Management Source Type: research
This study aims to evaluate whether certain language and other characte...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Media, Marketing, and Internet Issues Source Type: news
BACKGROUND: Various associations between monthly Google search volumes (MGSVs) and monthly suicide rates (MSRs) have been reported. However, these studies often analyzed a limited number of search terms using suboptimal statistical methods. While controlli...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Media, Marketing, and Internet Issues Source Type: news
BACKGROUND: The use of computers/TV has become increasingly common worldwide after entering the twenty-first century and depression represents a growing public health burden. Understanding the association between screen time-based sedentary behavior (ST-SB...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Media, Marketing, and Internet Issues Source Type: news
BACKGROUND: Depressed patients presenting to emergency departments with acute suicidal ideation are a major public health concern. Ketamine, a rapidly acting antidepressant with antisuicidal properties, might offer relief. METHODS: In a randomized,...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Program and Other Evaluations, Effectiveness Studies Source Type: news
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