Bill Gates Makes Hopeful Predictions for Global Health

Bill Gates told an audience at the University of Cambridge on Monday that global malnutrition will be solved and malaria will be virtually eliminated by 2040 if world leaders choose to fund scientific innovation. Speaking at the Cambridge Union in England, the Microsoft co-founder said: “I’m lucky that my work gives me a view of all the amazing discoveries in the works right now. That’s why I’m able to predict the future.” Gates was named the 2019 recipient of the Professor Hawking Fellowship, founded by the Cambridge Union Society in 2017 in honor of Stephen Hawking’s contribution to the university. Quoting a question Stephen Hawking asked in his final book, Brief Answers to the Big Questions, Gates asked the audience, “How do we shape the future?” The billionaire philanthropist is trying to shape the future by tackling global health issues and inequality at the Bill and Melinda Gates Foundation. On Monday, he predicted scientists will solve malnutrition and significantly reduce the number of nutrition-related deaths globally in the next 20 years. “By solving malnutrition, we can fix one of the biggest contributors to inequity,” he said. Malnutrition contributes to about half of deaths in children under the age of five, according to the World Health Organisation (WHO). Gates points to how scientists have developed solutions in recent years, including fortified foods or supplements packed with vitamins and minera...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized global health Source Type: news

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ve; M Abstract Malaria remains a serious problem in global public health, particularly widespread in South America and in tropical regions of Africa and Asia. Chemotherapy is actually the only way to treat this poverty-related disease, since an effective vaccine is not currently available. However, the onset of resistance to the most common antimalarial drugs sometimes makes the current therapeutic regimen problematic. Therefore, the identification of new targets for a new drug discovery process is an urgent priority. In this context, falcipain-2 and falcipain-3 of P. falciparum represent the key enzymes in the li...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
As we know,  Resident Dump is prone to magical thinking -- whatever pops into his head, that he says aloud, becomes true by the God-like power of his words. Three million illegal aliens voted for Hillary Clinton. His inaugural crowd was the biggest ever. The coronavirus is just going to disappear, you'll see, it will be like magic . . .I could go on endlessly but you already know that he's insane. So one of the nonsensical ideas that popped into his head was that an anti-malarial drug, hydroxychloroquine, is actually a miracle cure for Covid-19. That is biologically completely implausible -- it is toxic to the metazoa...
Source: Stayin' Alive - Category: American Health Source Type: blogs
In this study, an integrated approach was employed to identify promiscuous peptides of a well-defined sequence of erythrocyte binding antigen-175 and promiscuous peptides for HLA alleles were designed using bioinformatics tools. A peptide with 15 amino acids (ILAIAIYESRILKRK) was selected based on its high binding affinity score and synthesized. This promiscuous peptide was used as stimulating antigen in lymphoproliferative responses to evaluate the cellular immune response. It was observed this peptide evokes lymphoproliferative and cytokine responses in individuals naturally exposed to the malaria parasite. The intensity...
Source: Biologicals : Journal of the International Association of Biological Standardization - Category: Biotechnology Authors: Tags: Biologicals Source Type: research
Abstract The merozoite surface protein 9 (MSP9) of malarial parasite forms co-ligand complex with the 19 kDa fragment of merozoite surface protein 1 (MSP1) prior to erythrocyte invasion. Interruption of this process could hamper subsequent asexual erythrocytic development of malaria parasites; therefore, these proteins are considered potential vaccine candidates. In Plasmodium vivax, MSP9 (PvMSP9) contains both conserved and polymorphic repetitive domains that were immunogenic upon natural malaria exposure and conferred protection in vaccination studies in animal models. To investigate the extent of sequence div...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Vaccine development has the potential to be accelerated by coupling tools such as systems immunology analyses and controlled human infection models to define the protective efficacy of prospective immunogens without expensive and slow phase 2b/3 vaccine studies. Among human challenge models, controlled human malaria infection trials have long been used to evaluate candidate vaccines, and RTS,S/AS01 is the most advanced malaria vaccine candidate, reproducibly demonstrating 40 to 80% protection in human challenge studies in malaria-naïve individuals. Although antibodies are critical for protection after RTS,S/AS01 vaccinat...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Tanzanian adult male volunteers were immunized by direct venous inoculation with radiation-attenuated, aseptic, purified, cryopreservedPlasmodium falciparum(Pf) sporozoites (PfSPZ Vaccine) and protective efficacy assessed by homologous controlled human malaria infection (CHMI). Serum immunoglobulin G (IgG) responses were analyzed longitudinally using a Pf protein microarray covering 91% of the proteome, providing first insights into naturally acquired and PfSPZ Vaccine-induced whole parasite antibody profiles in malaria pre-exposed Africans. Immunoreactivity was identified against 2,239 functionally diverse Pf proteins, sh...
Source: eLife - Category: Biomedical Science Tags: Epidemiology and Global Health Source Type: research
In this study, we analyzed the diversity of AMA1 from BrazilianP.vivax isolates and 19 haplotypes ofP.vivax were found. Among those sequences, 33 nonsynonymous PvAMA1 amino acid sites were identified, whereas 20 of these sites were determined to be located in predicted B-cell epitopes. Nonsynonymous mutations were evaluated for their influence on the immune recognition of these antigens. Two distinct haplotypes, 5 and 16, were expressed and evaluated for reactivity in individuals from northern Brazil. Both PvAMA1 variants were reactive. Moreover, the IgG antibody response to these two PvAMA1 variants was analyzed in an exp...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Authors: Varo R, Chaccour C, Bassat Q Abstract Despite recent successful efforts to reduce the global malaria burden, this disease remains a significant global health problem. Only in 2018, malaria caused 228 million clinical episodes, 2-4 million of which were severe malaria cases, and 405,000 were fatal. Most of the malaria attributable mortality occurred among children in sub-Saharan Africa. Nowadays, rapid diagnostic tests and artemisinin derivatives are two of the main pillars for the management of malaria. However, considering the current situation, these strategies are not sufficient to maintain a reducing t...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Abstract In developed countries, it is said that "threats of infectious diseases are already thought as things of the past". However, as you can see in the case of Ebola hemorrhagic fever that occurred in West Africa, this is a big mistake. Among infectious diseases, only smallpox has been successfully eradicated worldwide. In addition to the three major infectious diseases of HIV/AIDS, tuberculosis, and malaria, there is another group called emerging and reemerging infectious diseases. Recently, neglected tropical diseases (NTDs) have been listed as threats by the WHO, as have drug-resistant bacteria. T...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
An effective vaccine to reduce malaria transmission is central to control and ultimately achieve disease eradication. Recently, we demonstrated that antibodies targeting the Plasmodium falciparum surface protein P47 (Pfs47) reduce parasite transmission to Anopheles gambiae mosquitoes. Here, Plasmodium berghei (Pb) was used as a model to assess the in vivo efficacy of a P47-targeted transmission blocking vaccine (Pbs47). Mice were immunized following a prime/boost regimen and infected with P. berghei. The effect of immunization on infectivity to mosquitoes was evaluated by direct feeding on P. berghei-infected mice. The key...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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