1.5 longitudinal diffusion tensor imaging study of adolescents and young adults with bipolar disorder

Longitudinal neuroimaging during adolescence/young adulthood, when bipolar disorder (BD) commonly emerges, can help elucidate the neurodevelopmental pathophysiology of BD. Adults with BD have shown reduced structural integrity in the uncinate fasciculus (UF), a white matter (WM) tract providing major connections between the amygdala and  ventral prefrontal cortex (vPFC), important in emotion regulation. In this longitudinal diffusion tensor imaging (DTI) study of adolescents/young adults, we hypothesized differences in age- and time-related changes in UF integrity in BD compared with healthy control (HC) subjects.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: 2018 Klingenstein Third Generation Foundation Award for Research In Depression or Suicide, Supported by the Klingenstein Third Generation Foundation Source Type: research