Bupropion Causes Misdiagnosis in Brain Dopamine Transporter Imaging for Parkinsonism

Conclusions Bupropion has previously generally been discontinued 1 week prior DAT imaging, which meets the recommended, albeit arbitrary, time interval of 5 plasma clearance half-lives before the scan. One-week discontinuation of bupropion before DAT imaging may be insufficiently short. Our case shows that longer medication washout and rescan may be needed when there is contradiction between the imaging result and clinical outcome in patients with medications affecting DAT binding.
Source: Clinical Neuropharmacology - Category: Neurology Tags: Case Reports Source Type: research