In vitro and in vivo assessment of the antibacterial activity of colistin alone and/or in combination with other antibiotics against A. baumannii and E. coli

ConclusionsThe effectiveness of COL alone in vitro and in vivo suggested that intravenous CMS will be an effective and available therapeutic strategy for UTI due to MDR gram-negative pathogens. In-depth in vitro tests demonstrated that COL combined with DOR could be an attractive option, especially when COL MIC of the pathogen is ≥ 1 μg/ml.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research

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Conclusions We present a quick, simple, and affordable method to decellularize a muscle flap through the vascular network. Our proposed method is efficient and can be completed in a significantly shorter time when compared with other methods. It is also safe and does not affect integrity of tissue, and this is essential for a reliable recellularization.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Transplantation Surgery and Research Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Membrane ScienceAuthor(s): Jiaqi Ding, Songlin Wang, Pengchao Xie, Yujia Zou, Ying Wan, Yongsheng Chen, Mark R. WiesnerAbstractThis paper presents an investigation of the variation in membrane characteristics and formation of halogenated by-products during the off-line chemical cleaning of algae-fouled ultrafiltration (UF) membrane by NaClO solution. The chemical treatment led to the recovery of membrane flux, decrease of membrane hydrophilicity and HA rejection. Proteins, amino acids, and polysaccharides contained in algal cells were easy to adsorb on t...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Publication date: Available online 12 November 2019Source: Journal of Materials Research and TechnologyAuthor(s): Ping Li, Yuan Zhang, Yingfeng Zuo, Jianxiong Lu, Guangming Yuan, Yiqiang WuAbstractTo improve the properties and added value of Chinese fir wood, sodium silicate-modified Chinese fir wood (SSMCF) was prepared by respiratory impregnation method. Phenol formaldehyde oligomer-modified Chinese fir wood (PFOMCF) as control sample, the impregnation and reinforcement effects, water resistance of PFOMCF and SSMCF were compared. The results showed that the weight percentage gain, density growth rate, bending strength, c...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Authors: Savaş Şen Z, Taşar MA, Demirel Kaya F, Güneş A, Vezir E, Hızarcıoğlu Gülşen H Abstract Cryptosporidium spp. is one of the leading causes of parasitic diarrhea. It is the most common parasite in humans all over the world with Giardia. Cryptosporidium is an important cause of chronic diarrhea in Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) patients. Patients with normal immune system may have an asymptomatic course or clinical presentation such as acute watery diarrhea without blood and persistent diarrhea. The severity and duration of the disease may be a re...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
In this report, a 60 years old woman with a past medical history of significant chronic kidney disease undergoing regular hemodialysis, chronic constipation and hepatitis B was admitted to our neurology clinic because of acute intracerebral hemorrhage. She had confusion and right hemiplegia in her neurological examination and required urinary catheterization due to immobilization. Red coloration was observed in urine on the tenth hospital day. Although this coloration was thought to be hematuria, according to urine examination it was not hematuria. Then urine color turned into purple within two days. The next day, because ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Authors: Öncel K Abstract Aim of the present study was to identify protozoones which are difficult to define through wet slide in fresh fecal samples by using different fixatives with modified Trichrome stain within five minutes. Two different fixatives prepared for the alternative approach. The slides were fixed by two different fixatives, one of them (fixative-1) was based ethylalcohol, formalin, acetic acid, distilled water and the other one (fixative-2) based ethylalcohol, formalin, citric acid, distilled water included a mordant [divalent or polyvalent metals which make coordination complex with some dyes...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
In conclusion, we emphasize that it is of importance to work closely with the hospital administration to take measures and that necessary assistance is provided. PMID: 31709934 [PubMed - in process]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Authors: Alp A, Sarıbaş Z Abstract One of the most important steps for the control of tuberculosis is rapid and accurate detection of Mycobacterium tuberculosis in clinical samples. The early and accurate diagnosis of tuberculosis allows the initiation of the effective treatment regimen as early as possible. However the early diagnosis of tuberculosis can be achieved by the integration of molecular methods into the diagnostic algorithm of tuberculosis together with the gold standard culture methods. For this reason, molecular methods have become valuable diagnostic tools in routine diagnostic laboratories in rece...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
This study aimed to investigate whether bioelectrical impedance measurements of body water could reduce the frequency of blood sampling for fluid replacement in patients with hypernatremia. MATERIAL AND METHODS Fifty-one hospitalized patients were studied with hypernatremia, defined as a serum sodium ≥150 mmol/L determined by laboratory testing. Laboratory and BIA measurements were compared, and water deficiency was calculated with a conventional formula (sodium-corrected Watson formula) and measured by BIA. RESULTS The value of the absolute fluid overload (AFO) equivalent to the overhydration (OH) value, determined usi...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conclusion: New carbapenem/βLI combinations may be viable alternatives to antimicrobial combination therapy as they displayed high efficacy in vitro and in vivo. Meropenem/Avibactam and Meropenem/Relebactam should be tested on larger sample sizes with different carbapenemases before progressing further in its preclinical development. Introduction Carbapenem resistant Gram-negative bacteria have been gradually increasing in prevalence in recent years. In the United States, the latest CDC Antibiotic Resistance Threat Report indicates that Carbapenem-Resistant Enterobacteriaceae (CREs) are responsible for 9,000 a...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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