In vitro and in vivo assessment of the antibacterial activity of colistin alone and/or in combination with other antibiotics against A. baumannii and E. coli

ConclusionsThe effectiveness of COL alone in vitro and in vivo suggested that intravenous CMS will be an effective and available therapeutic strategy for UTI due to MDR gram-negative pathogens. In-depth in vitro tests demonstrated that COL combined with DOR could be an attractive option, especially when COL MIC of the pathogen is ≥ 1 μg/ml.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research