Colistin plus meropenem combination is synergistic in vitro against extensively drug-resistant Pseudomonas aeruginosa, including high-risk clones
ConclusionsThese data suggest that colistin plus meropenem may be a useful combination for the treatment of infections due to XDR P. aeruginosa, including high-risk clones, which warrants evaluation in a clinical trial. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 20, 2019 Category: Infectious Diseases Source Type: research

Editorial Board
Publication date: June 2019Source: Journal of Global Antimicrobial Resistance, Volume 17Author(s): (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 19, 2019 Category: Infectious Diseases Source Type: research

In vitro interaction profiles of new anti-TB drugs Bedaquiline, Delamanid with Moxifloxacin against clinical isolates of Mycobacterium tuberculosis
ConclusionSynergistic and additive effects between these two drugs combinations offers an attractive chemotherapeutic regimens against all drug resistant clinical isolates. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 19, 2019 Category: Infectious Diseases Source Type: research

Antimicrobial susceptibility of Burkholderia pseudomallei isolates in Northern Vietnam
ConclusionThe results of this study suggest that currently recommended antibiotics for melioidosis treatment can be empirically used, but continuously monitoring antimicrobial susceptibility should be a concern. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 19, 2019 Category: Infectious Diseases Source Type: research

Genomic diversification of IncR plasmids from China
ConclusionsThis is a detailed comparative genomics analysis of IncR plasmids from China, providing a deeper insight into diversification and evolution of IncR plasmids. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 17, 2019 Category: Infectious Diseases Source Type: research

Frequency Distribution, Genotypes and the most Prevalent Sequence Types of New Delhi Metallo-beta-lactamase-Producing Escherichia coli among Clinical Isolates around the World; A Review
ConclusionsDistribution of NDM variants among E. coli strains is a serious threat to global public health. In addition, the most prevalent E. coli clonal groups such as ST101 and ST167 are one of the main causes of E. coli infection in different countries. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 16, 2019 Category: Infectious Diseases Source Type: research

Colonization with extended-spectrum beta-lactamase (ESBL) Enterobacteriaceae in pregnant/post-partum women: systematic review and meta-analysis
ConclusionsThere was heterogeneity regarding ESBL colonization rates in different continents. The pooled prevalence rate was higher in Africa compared to other areas. Given that the highest rate was observed in African studies, considering implementing screening efforts for ESBL colonization during pregnancy may be justified. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 16, 2019 Category: Infectious Diseases Source Type: research

Pharmacokinetics of Meropenem in Burn Patients with Infections Caused by Gram Negative Bacteria: Are We Getting Close to the Right Treatment?
ConclusionThese data suggest that a combined 2 h infusion with a higher dosage of meropenem, including a loading dose, may be successful to achieve effective PK parameters. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 16, 2019 Category: Infectious Diseases Source Type: research

Whole-genome sequencing of Enterococcus hirae CQP3-9, a strain carrying phenicol-oxazolidinone-tetracycline resistance gene poxtA of swine origin in china
ConclusionHere we first report the phenicol-oxazolidinone-tetracycline resistance gene poxtA in E. hirae, which is located on a plasmid that co-carries erm(B), fexB, tet(L) and tet(M). The genome sequence of E. hirae CQP3-9 provides valuable information for the dissemination of poxtA among enterococci. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 16, 2019 Category: Infectious Diseases Source Type: research

Use of colistin in adult patients: a cross-sectional study
ConclusionsColistin remains an important option for severe MDR-GNB infections when other treatments are not available. Despite inherent difficulties in optimizing its use due to peculiar PK/PD characteristics, colistin was mostly used appropriately in a country endemic for MDR-GNB. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 16, 2019 Category: Infectious Diseases Source Type: research

The emergence of metronidazole and vancomycin reduced susceptibility in Clostridium difficile isolates in Iran
This study was undertaken to evaluate the antimicrobial resistance patterns of toxigenic C. difficile isolates cultured from diarrhoeal stool samples of hospitalised patients with suspected CDI in three tertiary care hospitals in Tehran, Iran.MethodsTwo hundred and fifty diarrhoeal stool samples were investigated by toxigenic culture using cycloserine-cefoxitin-fructose agar and the VERO cell line. Antimicrobial susceptibility to metronidazole, vancomycin, clindamycin, tetracycline, and moxifloxacin was performed by disk diffusion and Etest methods on Brucella Blood Agar supplemented with hemin and vitamin K.ResultsThirty-...
Source: Journal of Global Antimicrobial Resistance - June 16, 2019 Category: Infectious Diseases Source Type: research

Nitro-Carba test, a novel and simple chromogenic phenotypic method for rapid screening of carbapenemase-producing Enterobacteriaceae
ConclusionThis assay is a promising method for detecting CPE rapidly. The NCT is a simple and reliable method capable of detecting CPE even in carbapenem-susceptible strains. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 16, 2019 Category: Infectious Diseases Source Type: research

Changing Epidemiology of KPC Producing Klebsiella pneumoniae in Argentina: Emergence of Hypermucoviscous ST25 and High Risk Clone ST307
ConclusionsDespite previous reports in Argentina, ST258 is no longer the absolute clone among KPC-Kp isolates. In the present study, the dissemination of more virulent lineages such as the hypermucoviscous ST25 was detected. Even more, it was noticed for the first time in our region the emergence of the high risk clone ST307 and also the occurrence of blaKPC-3. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 14, 2019 Category: Infectious Diseases Source Type: research

A Pilot Study on the Analytic Sensitivity and Accuracy of the Check-Points Check Direct CPE, Cepheid Xpert Carba-R and ChromID CARBA SMART chromogenic agar for the detection of carbapenemase-producing Enterobacteriaceae
Publication date: Available online 13 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Shawn Vasoo, Pei Yun Hon, Jung-Pu Hsu, Tse Hsien Koh, Partha P De (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 14, 2019 Category: Infectious Diseases Source Type: research

Integration of two pKPX-2 derived antibiotic resistance islands in the genome of an ESBL-producing Klebsiella pneumonia ST3483 from Lebanon
ConclusionThe sequenced genome revealed interesting aspects related to antibiotic resistance dissemination. The ARI are more stable in the genome and the chance of losing it is less probable, with the possibility of the described transposon to re-integrate in other plasmids, facilitating the dissemination of such resistance determinants. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 14, 2019 Category: Infectious Diseases Source Type: research

Co-delivery of buparvaquone and polymyxin B in nanostructured lipid carrier for leishmaniasis treatment
The objective of this study was to describe the preparation and in vitro evaluation of the surface modified nanostructured lipid carrier (NLC) using chitosan and dextran in the co-delivery of buparvaquone (BPQ) and polymyxin B (PB) against leishmaniasis.MethodsNLC was prepared using high high-pressure homogenization; polymyxin B binding and surface modifications with biopolymers were achieved by electrostatic interaction. In vitro cytotoxicity was assessed in mouse peritoneal macrophages and leishmanicidal activity, in amastigotes of L. infantum.ResultsThe performance attributes of BPQ-NLC, BPQ-NLC-PB[A-] (anionic) and BPQ...
Source: Journal of Global Antimicrobial Resistance - June 14, 2019 Category: Infectious Diseases Source Type: research

A new variant of mcr-1 identified from an extended-spectrum β lactamase-producing Escherichia coli
Publication date: September 2019Source: Journal of Global Antimicrobial Resistance, Volume 18Author(s): Yushan Cui, Jingjing Quan, Weichao Liao, Dongdong Zhao, Yan Jiang, Xiaoxing Du, Feng Zhao, Yunsong Yu (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 14, 2019 Category: Infectious Diseases Source Type: research

Successful treatment and digestive decolonization of a patient with osteitis caused by a Carbapenemase-producing Klebsiella pneumoniae isolate harboring both NDM-1 and OXA-48 enzymes
ConclusionThe ST307 type is becoming endemic in hospital environment and is frequently associated with carbapenem resistance. Treatment of infection caused by multi-drug resistant bacteria are a clinical challenge and the use of old antibiotics associated with a screening and decolonization of the reservoirs can be an efficient therapeutic alternative. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 13, 2019 Category: Infectious Diseases Source Type: research

Antimicrobial susceptibility testing and antibiotic consumption results from 16 hospitals in Viet Nam- the VINARES project, 2012-2013
ConclusionsThese data are valuable in providing a baseline for AMR among common bacterial pathogens in Vietnamese hospitals and to assess the impact of interventions. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 13, 2019 Category: Infectious Diseases Source Type: research

Prevalence of extended-spectrum β-lactamase-producing Klebsiella pneumoniae: First systematic review and meta-analysis from Iran
ConclusionThe prevalence of ESBL-KP has increased steadily in recent years among clinical K. pneumoniae isolates in Iran. Thus, initial identification of ESBL-KP according to Clinical and Laboratory Standards Institute (CLSI) guidelines, proper molecular approaches, and implementation of antimicrobial stewardship programmes in Iranian hospitals together with comprehensive infection control measures are urgently needed to control the dissemination of these strains. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 13, 2019 Category: Infectious Diseases Source Type: research

Antifungal stewardship with emphasis on candidaemia
Publication date: Available online 11 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Malini R Capoor, Chinari P Subudhi, Andrew Collier, Abhijit M BalAbstractAntimicrobial resistance is a global threat. To counter the growing menace of antibiotic resistance, several stewardship initiatives have been incorporated a part of overarching strategy of healthcare delivery. In comparison, antifungal stewardship has attracted limited attention due to several factors such as limited antifungal resistance and less burden of fungal infections compared to bacterial infections. However, emergence of resistant fung...
Source: Journal of Global Antimicrobial Resistance - June 11, 2019 Category: Infectious Diseases Source Type: research

Complete Genome Arrangement Revealed the Emergence of a Poultry Origin Superbug Citrobacter portucalensis Strain NR-12
ConclusionC. portucalensis NR-12 was resistant to 7 different antibiotics from 5 antimicrobial groups. Understanding of its resistant mechanism is necessary to implicate control strategy. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 9, 2019 Category: Infectious Diseases Source Type: research

Prevalence, Antimicrobial resistance, virulence genes and class 1 integrons of Enterococcus faecium and Enterococcus faecalis from pigs, pork and humans in Thai-Laos border provinces
This study aimed to determine prevalence, antimicrobial resistance, virulence genes and class 1 integrons of Enterococcus faecium and Enterococcus fecalis from pig, pork and humans in Thailand-Laos border provinces.MethodsSix hundred and forty-eight (648) rectal and carcass swab samples from border provinces of Thailand (n = 359) and Lao PDR (n = 289) were collected from September 2013 to October 2014 and examined.ResultsThe over-all prevalence ofEnterococcus species was 483/648(75%), comprising of E. faecium 359/483(74.3%) and E. faecalis 124/483(25.7%). The occurrence of E. faecium in pig, pig...
Source: Journal of Global Antimicrobial Resistance - June 9, 2019 Category: Infectious Diseases Source Type: research

Distribution of embB mutations of Thai clinical isolates of ethambutol-resistant Mycobacterium tuberculosis
Publication date: Available online 8 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Orawan Tulyaprawat, Angkana Chaiprasert, Piriyaporn Chongtrakool, Kamol Suwannakarn, Popchai Ngamskulrungroj (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 9, 2019 Category: Infectious Diseases Source Type: research

Complete genome sequence of an IMP-8, CTX-M-14, CTX-M-3, and QnrS1 co-producing Enterobacter asburiae strain isolated from a patient with wound infection
ConclusionsTo our knowledge, this is the first complete genome sequence of E. asburiae strain co-producing IMP-8, CTX-M-14, CTX-M-3, and QnrS1. This genome may facilitate the understanding of resistome, pathogenesis, and genomic features of E. cloacae complex, and will provide valuable information for accurate identification of E. cloacae complex. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 8, 2019 Category: Infectious Diseases Source Type: research

NDM and other mechanisms of carbapenemases among Enterobacteriaceae in rural South India
ConclusionsThe study documented the MIC range for carbapenems, prevalence, and mechanisms of carbapenem resistance in rural South India; substantiated, NDM as a leading mechanism of carbapenem resistance and highlighted the importance of MIC testing in patient maagement. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 8, 2019 Category: Infectious Diseases Source Type: research

Evaluating the optimal time for amikacin administration with respect to haemodialysis using an in vitro pharmacodynamic simulation against epidemic nosocomial OXA-48 producing Klebsiella pneumoniae ST405 strains
Publication date: Available online 6 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Antonio J. Carcas, David Sevillano, Natalia González, Luis Alou, Rosa Gómez-Gil, Mario Muñoz, Lucia Llanos, Rafael J. Sanchez-Villanueva, Emilio Gonzalez-Parra, Maria-Jose Giménez, Lorenzo AguilarAbstractObjectivesBacterial viability and enrichment of resistance resulting from three different amikacin administration schedules with respect to haemodialysis (HD) were assessed against three OXA-48-producing Klebsiella pneumoniae (OXA48KP) strains isolated during an outbreak in Hospital Univers...
Source: Journal of Global Antimicrobial Resistance - June 7, 2019 Category: Infectious Diseases Source Type: research

Global economic impact of antibiotic resistance: A review
Publication date: Available online 5 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Mohammad Ahmad, Asad U. KhanAbstractThe pandemic of antibiotic resistance has become a serious threat to the therapeutic efficacy of the available antibiotics and their prescribed regimen. The problem is multifaceted as it encompasses medical, social, economic and anthropogenic spheres. The present review reports the global economic impact of antibiotic resistance among humans on the basis of published researches and reports of national and international organizations. The impacts are catastrophic because it includes ...
Source: Journal of Global Antimicrobial Resistance - June 6, 2019 Category: Infectious Diseases Source Type: research

Long-read Nanopore Sequencing-based Draft Genome of a Carbapenem-resistant Pseudomonas aeruginosa
ConclusionsThe draft genome sequence of carbapenem-resistant P. aeruginosa could provide a solid basis for further research on the resistance mechanism and the development of drug therapy for drug resistant genes. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 6, 2019 Category: Infectious Diseases Source Type: research

Genetic mutations at the quinolone resistance-determining region are related to changes in the epidemiological profile of methicillin-resistant Staphylococcus aureus isolates
ConclusionsThis study highlighted an increase in number and types of mutations at QRDR of gyrA and parC genes associated with high fluoroquinolones MIC that may be related to changes in the epidemiological profile of MRSA isolates from hospitals in Rio de Janeiro. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 6, 2019 Category: Infectious Diseases Source Type: research

Eukaryotic cell culture media affects macrolide MICs but not resistance interpretations for foodborne pathogens
Publication date: Available online 5 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Gregory H. Tyson, Sherry Ayers, Claudia Lam, Ron A. Miller, Marilyn N. Martinez (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 6, 2019 Category: Infectious Diseases Source Type: research

Draft genome sequence of a multidrug-resistant blaOXA-69-producing Acinetobacter baumannii L13 isolated from Tarim River sample in China
ConclusionsThe genome sequence of A. baumannii L13 reported here will benefit the comparative analysis of the genus Acinetobacter, and promote further understanding of the specific genomic feature in terms of multidrug resistance in A. baumannii. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 6, 2019 Category: Infectious Diseases Source Type: research

Corrigendum to “Whole-genome sequencing reveals genetic signature of bedaquiline resistance in a clinical isolate of Mycobacterium tuberculosis” [J Glob Antimicrob Resist 15 (2018) 103–104]
Publication date: Available online 3 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Kiran Chawla, Elena Martinez, Ajay Kumar, Vishnu Prasad Shenoy, Vitali Sintchenko (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 4, 2019 Category: Infectious Diseases Source Type: research

Growth in the presence of specific antibiotics induces biofilm formation a Campylobacter jejuni strain sensitive to them but not in resistant strains
ConclusionThe ability of certain antibiotics to induce biofilm formation by aC. jejuni strain tested is of concern with respect to the effective control of disease caused by this pathogen but further work is required to confirm how widespread this feature is. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 2, 2019 Category: Infectious Diseases Source Type: research

First report of linezolid-resistant cfr-positive methicillin-resistant Staphylococcus aureus in humans in Portugal
Publication date: June 2019Source: Journal of Global Antimicrobial Resistance, Volume 17Author(s): Vanessa Silva, Francisco Almeida, Adriana Silva, Susana Correia, José António Carvalho, Ana Paula Castro, Eugénia Ferreira, Vera Manageiro, Manuela Caniça, Gilberto Igrejas, Patrícia Poeta (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - June 2, 2019 Category: Infectious Diseases Source Type: research

A new variant of mcr-1 identified from an extended-spectrum β lactamase -producing Escherichia coli
Publication date: Available online 30 May 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Yushan Cui, Jingjing Quan, Weichao Liao, Dongdong Zhao, Yan Jiang, Xiaoxing Du, Feng Zhao, Yunsong Yu (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 31, 2019 Category: Infectious Diseases Source Type: research

Potent cationic antimicrobial peptides against Mycobacterium tuberculosis in vitro
ConclusionsThe characteristic proprieties of Cin + CAMP(n) can successfully inhibit the growth of both clinical isolatesMtb and MDR in vitro and hold, for now, a promising usage as drug adjuvant due to its effect on mycobacteria growth. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 31, 2019 Category: Infectious Diseases Source Type: research

Colistin plus meropenem combination is synergistic in vitro against extensively drug-resistant (XDR) Pseudomonas aeruginosa, including high-risk clones
ConclusionsThese data suggest that colistin plus meropenem may be a useful combination for the treatment of infections due to XDR P. aeruginosa, including high-risk clones, which warrants evaluation in a clinical trial. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 31, 2019 Category: Infectious Diseases Source Type: research

Do antimicrobial stewardship programme interventions reduce the rate of and protect against Clostridium difficile infection?
This study aimed to evaluate whether ASP interventions have contributed to reducing CDI rates.MethodsA retrospective review of ASP interventions issued from January 2013 to April 2014 was performed using data from the ASP database of Singapore General Hospital, a 1600-bed tertiary-care hospital in Singapore. A total of 283 interventions satisfied the inclusion criteria, of which commonly audited antibiotics were piperacillin/tazobactam (41.3%) and carbapenems (54.8%). Comparisons were made at 30 days post-intervention between those with accepted or rejected interventions. The primary outcome was CDI incidence; seconda...
Source: Journal of Global Antimicrobial Resistance - May 31, 2019 Category: Infectious Diseases Source Type: research

Mutant selection window of disinfectants for Staphylococcus aureus and Pseudomonas aeruginosa
ConclusionsThis is the first evaluation of the bactericidal activity against S. aureus and P. aeruginosa strains surviving in the MSW of disinfectants. Environmental disinfection at low concentrations of sodium hypochlorite does not kill micro-organisms. Proper use of sodium hypochlorite shows a bactericidal effect against various pathogenic micro-organisms and is inexpensive, making it frequently used globally. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 31, 2019 Category: Infectious Diseases Source Type: research

First report of the new emerging global clone ST1193 among clinical isolates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli from Germany
ConclusionsThis study revealed for the first time in Germany the occurrence of ST1193 among clinical isolates of ESBL-producing E. coli. Further national or regional multicentre studies are needed to assess the effective relevance of ESBL-producing E. coli ST1193 as a nosocomial pathogen in Germany. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 29, 2019 Category: Infectious Diseases Source Type: research

Detection of transferable oxazolidinone resistance determinants in Enterococcus faecalis and Enterococcus faecium of swine origin in Sichuan Province, China
ConclusionOur study highlights the fact that mobile genetic elements, such as plasmids, IS1216E, Tn554 and Tn558, may facilitate the horizontal transmission of optrA or poxtA. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 26, 2019 Category: Infectious Diseases Source Type: research

Study of rdxA and frxA genes mutations in metronidazole-resistant and -susceptible Helicobacter pylori clinical isolates from the central region of Portugal
ConclusionsThis work appears to confirm that mutations in rdxA and frxA alone are unable to explain MTZ resistance in H. pylori isolates and therefore additional mechanisms may exist and should be investigated. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 25, 2019 Category: Infectious Diseases Source Type: research

Antimicrobial stewardship programme in a trauma centre of a tertiary care hospital in North India: Effects and implementation challenges
This study evaluated the implementation challenges of an ASP in a tertiary trauma care centre in India and its effect on antimicrobial prescription.MethodsA pre- and post-intervention study design was used to compare the effects of the ASP amongst patients admitted during November 2017–January 2018. The appropriateness of antimicrobial prescriptions (dose, route, duration, indication, choice) was evaluated using a validated algorithm. ASP interventions involved daily audit and feedback, restriction on antibacterial usage, daily bedside review, education, and sensitisation activities for residents/nurses. Key implemen...
Source: Journal of Global Antimicrobial Resistance - May 25, 2019 Category: Infectious Diseases Source Type: research

Draft genome sequence of a multidrug-resistant Escherichia coli ST189 carrying several acquired antimicrobial resistance genes obtained from Brazilian soil
ConclusionThis is the first draft genome sequence of an E. coli ST189 isolate serotype O80:H26-fimH54 obtained from soil. This draft genome sequence can be used to compare antimicrobial resistant E. coli isolates obtained from different sources. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 22, 2019 Category: Infectious Diseases Source Type: research

First report of linezolid-resistant cfr-positive methicillin-resistant Staphylococcus aureus (MRSA) in humans in Portugal
Publication date: Available online 22 May 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Vanessa Silva, Francisco Almeida, Adriana Silva, Susana Correia, José António Carvalho, Ana Paula Castro, Eugénia Ferreira, Vera Manageiro, Manuela Caniça, Gilberto Igrejas, Patrícia Poeta (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 22, 2019 Category: Infectious Diseases Source Type: research

Detection and Molecular Characterization of Amikacin-resistant Mycobacterium abscessus Isolated from Patients with Pulmonary Disease
ConclusionThe AMK resistance rate in M. abscessus clinical strains isolated in this study was low. Mutation of A1408 G in rrs and overexpression of WhiB7 and Tap were the predominant mechanisms of AMK resistance in M. abscessus. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 22, 2019 Category: Infectious Diseases Source Type: research

Elucidation of drug resistant mutations of Mycobacterium tuberculosis by whole genome sequencing from North India
ConclusionWhole-Genome Sequencing ofMycobacterium tuberculosis offers the detection of drug resistance to all drugs in a single test and also provides insight into the evolution and drug-resistant tuberculosis. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 22, 2019 Category: Infectious Diseases Source Type: research

Molecular typing of a large nosocomial outbreak of Klebsiella pneumoniae Carbapenemase-producing bacteria in the biggest third level hospital of Quito, Ecuador
ConclusionData indicate that KPC-producing polyclonalK. pneumoniae are frequent causes of nosocomial hospital outbreaks in South America. Similar genotypes have been reported in Colombia, Argentina and Brazil, North America and Asia. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - May 21, 2019 Category: Infectious Diseases Source Type: research

Measurement and prediction of antimicrobial resistance in bloodstream infections by ESKAPE and Escherichia coli pathogens
Publication date: Available online 18 May 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Giuseppe Vittorio De Socio, Paola Rubbioni, Daniele Botta, Elio Cenci, Alessandra Belati, Riccardo Paggi, Maria Bruna Pasticci, Antonella MencacciAbstractObjectivesThe aim of the study was to evaluate a cumulative antimicrobial resistance index (ARI) as a possible key outcome measure of antimicrobial stewardship (AS) programs and as a tool to predict antimicrobial resistance (AMR) trend.MethodsAntibiotic susceptibility for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pse...
Source: Journal of Global Antimicrobial Resistance - May 19, 2019 Category: Infectious Diseases Source Type: research