The relationship between maternal adiposity during pregnancy and fetal kidney development and kidney function in infants: the Gomeroi gaaynggal study

The aim of the current study was to examine whether there was an association between maternal adiposity and fetal kidney growth in late gestation (>28  weeks) and kidney function in infants,<2.5  years of age, in Indigenous babies from the Gomeroi gaaynggal cohort. Estimated fetal weight (EFW), but not fetal kidney size, was positively associated with maternal adiposity and pre‐pregnancy BMI. When adjusted for smoking, combined kidney volume relative to EFW was negatively associated with maternal percentage body fat. Current findings suggest that Indigenous babies born to obese mothers may have glomerular hyperfiltrationin utero, possibly because reduced kidney size relative to EFW is related to fewer nephron numbers, predisposing them to a higher risk of chronic kidney disease  (CKD) in later life. AbstractMaternal obesity during pregnancy has a detrimental impact on offspring renal development and function. This is pertinent to Indigenous Australians as they are twice as likely as non ‐Indigenous Australians to develop chronic kidney disease (CKD). The aim of this study was to examine whether there was an association between maternal adiposity and fetal kidney growth in late gestation (>28  weeks) and kidney function in infants,<2.5  years of age, from theGomeroi gaaynggal cohort. Pre ‐pregnancy body mass index (BMI) was recorded at the first prenatal visit and maternal adiposity indicators (percent body fat and visceral fat area) measured at>28  ...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research