Analgesic Effect of the Midazolam-induced Anesthesia in Different Doses on the Patients after the Thoracoscopic Resection of Lung Cancer

Publication date: Available online 13 September 2019Source: Saudi Journal of Biological SciencesAuthor(s): Lixia Zhang, Gang Wang, Jianhui Gan, Zhongci Dou, Liying BaiAbstractObjectiveTo elaborate the analgesic efficiency of midazolam-induced anesthesia in different doses on the patients following the thoracoscopic resection of lung cancer.MethodsNinety patients undergoing thoracoscopic resection of lung cancer between August 2017 and July 2018 were randomized in the observation group (n=45) and the control group (n=45). Patients in observation group underwent the anesthesia induced by 0.1 mg/kg midazolam, while for the control group, the dose was adjusted to 0.05 mg/kg. Then, we compared the levels of inflammatory factors, SaO2, average of arterial pressure and changes in heart rate before and after surgery (48 h) to analyze the efficacy.ResultsAt the postoperative 48 h, patients in the observation group had lower levels of inflammatory factors when comparing with their counterparts in the control group [IL-6, IL-8, IL-1β and TNF-α: (58.44±3.22) μg/L, (2.04±0.26) μg/L, (2.98±0.44) μg/L, (5.33±0.77) μg/L v.s. (96.44±4.54) μg/L, (3.23±0.33) μg/L, (3.77±0.44) μg/L, (7.64±0.99) μg/L] (P
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research

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Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
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Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Surgery Today - Category: Surgery Source Type: research
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Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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Source: Science - The Huffington Post - Category: Science Source Type: news
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