Genotyping of Candida albicans isolates from oropharyngeal candidiasis in head & neck cancer patients in Iran: Molecular epidemiology and SAP2 gene expression

Conclusion: We found few genetically-related as well as identical isolates among the 32 Candida strains which indicated low cross-contaminations among the patients. There was no relationship between C. albicans MLST profiles and their geographic distribution, cancer type and SAP2 gene expression. This lack of correlation was possibly due to the small understudy population; hence, finding more relevance requires studies with a higher number of samples.
Source: Journal of Medical Mycology - Category: Biology Source Type: research

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CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer. PMID: 31630150 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
His research brought an end to radical mastectomy, and he pioneered the design and implementation of large-scale multi-institutional randomized clinical trials.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
The current clinical study is aimed at evaluating the clinical relevance of an innovative device (called CyPaM2 device) that for the first ...
Source: Journal of the Optical Society of America A - Category: Physics Authors: Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: Available online 20 October 2019Source: Protein Expression and PurificationAuthor(s): Lei Jing, Juanjuan Liu, Dongxu Cui, Yuyin Li, Zhenxing Liu, Li Tao, Qing Zhao, Aipo DiaoAbstractAn affibody is a 58 amino acids peptide derived from the Z domain of staphylococcal protein A and generally applied in areas such as imaging diagnosis, clinical therapeutics and biotechnology research. To screen for an affibody targeting the immune checkpoint PD-L1, a combinatorial affibody library was generated in yeast using degenerate overlap PCR primers and In-fusion technology. Z-j1 and Z-j2 affibodies targeting the Ig-li...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: January 2020Source: Phytochemistry, Volume 169Author(s): Behnaz Tohidi, Mehdi Rahimmalek, Ahmad Arzani, Helena TrindadeAbstractThyme (Thymus spp.) is a valuable genus of Lamiaceae family with different pharmaceutical and food properties. Thymol has also been considered as the major essential oil compound in most of the studied Thymus species. In this research, the gene encoding γ-terpinene synthase (Ttps2) was sequenced in T. vulgaris and in eight Iranian thymes including T. carmanicus, T. daenensis, T. fedtschenkoi, T. kotschyanus, T. migricus, T. pubescens, T. se...
Source: Phytochemistry - Category: Chemistry Source Type: research
In this study, a chemometric strategy was developed for analysis of gas chromatographic (GC) and infrared spectroscopic (FT-IR) fingerprints of nine crude oil samples from the main oil wells of Iran to classify them and to find their origins. In this regard, a fractionation method based on saturated, aromatic, resin, and asphaltene (SARA) test was used. Then, these fractions were analyzed by GC-FID and GC-MS. Also, nine crude oil samples were analyzed by FT-IR.The obtained GC fingerprints were aligned using correlation optimized warping (COW) and auto-scaled, and then analyzed using principal component analysis (PCA) and h...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 October 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Jing Xu, Lan Bai, Yi-Ying Gu, Fan Du, Wen-Yao Zhang, Miao He, Yun-Jun LiuAbstractThree iridium(III) complexes [Ir(ppy)2(DQPC)](PF6) (Ir-1), [Ir(bzq)2(DQPC)](PF6) (Ir-2) and [Ir(piq)2(DQPC)](PF6) (Ir-3) were synthesized and characterized. The cytotoxicity in vitro of the ligand DQPC and complexes Ir-1, Ir-2 and Ir-3 against cancer cells HeLa, A549, HepG2 and normal cell NIH3T3 was assessed by MTT methods. These complexes exhibit significant inhibitory effect on HeLa cells growth with an IC50 value of 2.4 ± 0.2, 2.4 ...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Publication date: Available online 20 October 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Shun Yang, Jie Fan, Shiting Lin, Yaru Wang, Chang LiuAbstractAlthough the biodegradability of silica has been verified, the complete and safe excretion of mesoporous silica nanoparticles (MSNs) from the biological system still impede their clinical translation. Herein, novel pH-responsive biodegradable hollow mesoporous organosilica nanoparticles (PBHMONs) based on pH-responsive silsesquioxane were successfully prepared for efficient anti-cancer drug delivery. pH-responsive cleavable bridges ...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Hydrogels are hydrophilic three-dimensional networks able to hold large amount of water and hydrophilic molecules. Magneto-responsive hydrogels comprise of magnetic nanoparticles dispersed in polymeric networks that can be manipulated under external magnetic field. This review aims at (i) giving a brief overview on the evolution of hydrogels until the design and development of magnetic hydrogels; (ii) describing the types of hydrogels and the basic concepts about superparamagnetic iron oxide nanoparticles, as well as the preparation and characterization of magneto-responsive hydrogels; (iii) displaying the relevant applica...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
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