What is the mechanism of ventricular tachycardia in hypertrophic cardiomyopathy ?

Take Our Poll In HCM every myocyte is  genetically made  defective . Myofibrils are in disarray every where . Still , can we identify some vulnerable zones that acts as arrhythmic  focus ? If that is possible , we  have a opportunity to abate that focus . In HOCM  , which is the most stressed area ? LVOT ?  Septum, ? When we say stress , it can mean either mechanical or electrical . Does electrical instability involve the same zone as mechanical stress ? How often VT originate from LVOT in HCM ?  For this we have good clinical model _, the patients who underwent alcohol septal ablation. What happens to the incidence of VT  post septal  ablation  ? “It is reported  post septal ablation the incidence of SCD  becomes  equal to general population” (Read the paper below ) If that is true , it is obvious the  arrhythmic  focus is also ablated along with LVOT myocardium . Though many studies claim  so !  It  fails to convince us  .  HOCM is a diffuse disease of  myocardium.  Even a cluster of myocyte disarray  with fibrosis   can be a future focus  irrespective of it’s location . However ,  it is always possible relieving the mechanical stress of the LV can definitely reduce the likelihood of an electrical event .(Even if the arrhythmic focus is intact elsewhere !) * We know RVOT is  developmentally arrhythmia prone zone . We also know HCM involves RVOT (After all ,  IVS  is legally shared by both ventricles !  ) . Some of  the mo...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: cardiology -Therapeutics Cardiology -unresolved questions Cardiology-Arrhythmias Infrequently asked questions in cardiology (iFAQs) hocm hypertrophic obstructive cardiomyopathy lvot vt in hocm mechanism of vt in hocm mechansim of vt in hcm Source Type: blogs