488 Possible immunological mechanisms of developing extramammary Paget ’s disease through Malassezia-derived aryl hydrocarbon receptor ligands pathways

Malassezia yeast plays a role in the pathogenesis of chronic dermatitis, especially in apocrine areas, by polarizing the local immunologic background to a Th2/Th17 state through aryl hydrocarbon receptor (AhR)-dependent pathways. Extra-mammary Paget ’s disease (EMPD) is an adenocarcinoma of apocrine origin and, except for cases associated with Malassezia yeast and their metabolites, the lesions typically develop in areas not exposed to environmental material. The purpose of this study was to investigate 1) the immunomodulatory effects of Mala ssezia metabolites on normal human keratinocytes (NHKCs), focusing on interleukin (IL)-17 and related cytokines/chemokines (IL-23, IL-36g, CCL20), 2) the expression of these factors in lesion-affected skin in EMPD, and 3) the activation of tumor-associated macrophages (TAMs) by the productions of IL -17 induced factors.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research