Pressure Damage to Capillaries and Surrounding Cells in the Brain as a Contributing Cause of Cognitive Decline

Progressive arterial stiffness with age causes hypertension, a state of chronically raised blood pressure, which in turn damages sensitive tissues in the brain and other organs. Over time that means a loss of function and cognitive decline. Researchers here suggest that even without the increase in blood pressure, stiffness in larger blood vessels will redistribute pressure in a way that will harm cells near to smaller capillary vessels. What causes arterial stiffening? A combination of damage and dysfunction such as, for example: persistent cross-links degrade elasticity in the extracellular matrix of blood vessel walls; senescent cells and the chronic inflammation that they cause creates calcification of tissue, as well as poor function of smooth muscle tissue responsible for blood vessel constriction and dilation; mitochondrial dysfunction in smooth muscle cells also contributes. The fact that human memory is deteriorating with increasing age is something that most people experience sooner or later, even among those who avoid diseases such as Alzheimer's. Similarly, a connection between the ageing of the brain and the body is well known. However, the exact nature of this association is not known. Researchers have created an explanatory model that starts with the heartbeat, and carries through the largest arteries in the body all the way to the finest vessels in the brain. An important feature of the model is that it provides a rationale why some cognitive processe...
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In conclusion, older adults exhibited decreased markers of UPR activation and reduced coordination with autophagy and SC-associated gene transcripts following a single bout of unaccustomed resistance exercise. In contrast, young adults demonstrated strong coordination between UPR genes and key regulatory gene transcripts associated with autophagy and SC differentiation in skeletal muscle post-exercise. Taken together, the present findings suggest a potential age-related impairment in the post-exercise transcriptional response that supports activation of the UPR and coordination with other exercise responsive pathways (i.e....
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In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
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