Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in MPTP ‐induced Parkinson's disease in mice

This study aimed to further investigate whether two different forms of Lf have neuroprotective effectsin vivo, and to examine their mechanisms, so as to provide an experimental basis for finding new therapeutic strategies against PD. In the central nervous system, Lf antagonized 1 ‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced DA depletion in the striatum, iron deposition, oxidative and apoptotic processes in the SN. Lf treatment down‐regulated iron import protein divalent metal transporter1 (DMT1) and up‐regulated iron export protein ferroportin1 (Fpn1), attenuating MPTP induced accumulation of nigral iron level. In the peripheral system, Lf alleviated MPTP‐induced increases in serum iron and ferritin, and decreases in serum total iron binding capacity (TIBC), loss of spleen weight, and reduction of spleen iron content. The results indicat e that Lf has a neuroprotective effect on MPTP‐induced PD model mice, and its mechanism may be related to anti‐iron dysregulation, anti‐oxidative stress, and anti‐apoptosis, with apo‐Lf showing greater efficacy. Therefore, Lf might be a promising therapeutic substance for PD.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Original Article Source Type: research