Does glucagon-like peptide-1 (GLP-1) induce diuresis and natriuresis by modulating afferent renal nerve activity?

Does glucagon-like peptide-1 (GLP-1) induce diuresis and natriuresis by modulating afferent renal nerve activity? Am J Physiol Renal Physiol. 2019 Aug 07;: Authors: Katsurada K, Nandi SS, Sharma NM, Zheng H, Liu X, Patel KP Abstract Glucagon-like peptide-1 (GLP-1), incretin hormone, has diuretic and natriuretic effects. The present study was designed to explore the possible underlying mechanisms for the diuretic and natriuretic effects of GLP-1 via renal nerves in rats. Immunohistochemistry revealed that GLP-1 receptors were avidly expressed in the pelvic wall being adjacent to afferent renal nerves immunoreactive to calcitonin-gene-related peptide, which is the dominant neurotransmitters for renal afferents. GLP-1 (3 μM) infused into left renal pelvis increased ipsilateral afferent renal nerve activity (110.0 ± 15.6% of basal value). Intravenous infusion of GLP-1 (1 µg/kg/min) for 30 min increased renal sympathetic nerve activity (RSNA). After cutting the distal end of the renal nerve to eliminate the afferent signal, increase in efferent renal nerve activity during intravenous infusion of GLP-1 was diminished compared with the increase in total RSNA (17.0 ± 9.0% vs. 68.1 ± 20.0% of basal value). Diuretic and natriuretic responses to intravenous infusion of GLP-1 were enhanced by total renal denervation (T-RDN) with acute surgical cutting of the renal nerves. Selective afferent renal nerve denervation (A-RDN) was performed by b...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research