Ly6C+ Inflammatory Monocyte Differentiation Partially Mediates Hyperhomocysteinemia-Induced Vascular Dysfunction in Type 2 Diabetic db/db Mice.

CONCLUSIONS: Hyperhomocysteinemia potentiated systemic and vessel wall inflammation and vascular dysfunction partially via inflammatory monocyte subset induction in T2DM. Inflammatory monocyte may be a novel therapeutic target for insulin resistance, inflammation, and cardiovascular complications in hyperhomocysteinemia+T2DM. PMID: 31366217 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31366217?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 31, 2019 Category: Cardiology Authors: Fang P, Li X, Shan H, Saredy JJ, Cueto R, Xia J, Jiang X, Yang XF, Wang H Tags: Arterioscler Thromb Vasc Biol Source Type: research