Cancers, Vol. 11, Pages 1057: Mining of Self-Organizing Map Gene-Expression Portraits Reveals Prognostic Stratification of HPV-Positive Head and Neck Squamous Cell Carcinoma
Cancers, Vol. 11, Pages 1057: Mining of Self-Organizing Map Gene-Expression Portraits Reveals Prognostic Stratification of HPV-Positive Head and Neck Squamous Cell Carcinoma
Cancers doi: 10.3390/cancers11081057
Authors:
Locati
Serafini
Iannò
Carenzo
Orlandi
Resteghin
Cavalieri
Bossi
Canevari
Licitra
De Cecco
Patients (pts) with head and neck squamous cell carcinoma (HNSCC) have different epidemiologic, clinical, and outcome behaviors in relation to human papillomavirus (HPV) infection status, with HPV-positive patients having a 70% reduction in their risk of death. Little is known about the molecular heterogeneity in HPV-related cases. In the present study, we aim to disclose the molecular subtypes with potential biological and clinical relevance. Through a literature review, 11 studies were retrieved with a total of 346 gene-expression data points from HPV-positive HNSCC pts. Meta-analysis and self-organizing map (SOM) approaches were used to disclose relevant meta-gene portraits. Unsupervised consensus clustering provided evidence of three biological subtypes in HPV-positive HNSCC: Cl1, immune-related; Cl2, epithelial–mesenchymal transition-related; Cl3, proliferation-related. This stratification has a prognostic relevance, with Cl1 having the best outcome, Cl2 the worst, and Cl3 an intermediate survival rate. Compared to recent literature, which identified immune and keratinocyte subtypes in HPV-related HNSCC, we confir...
Source: Cancers - Category: Cancer & Oncology Authors: Locati Serafini Iann ò Carenzo Orlandi Resteghin Cavalieri Bossi Canevari Licitra De Cecco Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Epidemiology | Epithelial Cancer | Genetics | Genital Warts | Head and Neck Cancer | HNSCC | Human Papillomavirus (HPV) | Molecular Biology | Skin Cancer | Squamous Cell Carcinoma | Study