Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma: A case report and literature review
Rationale:
Endometrial neuroendocrine carcinoma is a rare histological subtype of endometrial cancer, divided into low-grade neuroendocrine carcinoma (carcinoid) and high-grade neuroendocrine carcinoma (small cell and large cell neuroendocrine carcinoma). It is characterized by high invasiveness and poor prognosis. L/SCNEC is an extremely rare pathological type of endometrial carcinoma, and the number of reports on this condition is few globally.
Patient concerns:
A 54-year-old Chinese female presented with vaginal bleeding.
Diagnoses:
Outpatient hysteroscopy and endometrial biopsy were performed, and the pathological examination revealed that cervix was invaded by endometrial malignancy. The patient underwent a laparoscopic radical hysterectomy was diagnosed with the mixed large and small cell neuroendocrine carcinoma (L/SCNEC) of the endometrium combined with serous carcinoma III C2 (FIGO2009).
Interventions:
Chemotherapy-radiotherapy-chemotherapy “sandwich” treatment was performed as postoperative therapy.
Outcomes:
After three chemotherapy circles, the patient showed no evidence of further disease progression.
Lessons:
L/SCNEC is a rare and invasive disease. Once diagnosed, comprehensive treatments including surgery, radiotherapy, and chemotherapy can prolong the survival of patients and improve the prognosis.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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