Genetic and Environmental Contributors for Celiac Disease

AbstractPurpose of ReviewCeliac disease (CD) is an autoimmune enteropathy triggered by gluten. The purpose of this review is to examine the major genetic and environmental factors that contribute to CD pathogenesis.Recent FindingsWe reviewed the current state of knowledge on the genetic and environmental components that play a role in CD onset. A genome-wide association study (GWAS) analysis has highlighted several genes other than HLA involved in CD. Recent studies have shown that HLA haplotype influences the microbiome composition in infants and that dysbiosis in the intestinal microflora, in turn, contributes to loss of tolerance to gluten. Recently, observational studies have discussed the hypothesis stating that breast-feeding had a protective role against CD onset.SummaryCD etiology is influenced by genetic and environmental factors. A better understanding of these components would deepen our knowledge on the mechanisms that lead to loss of tolerance and could help in developing a more “personalized medicine.”
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research

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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates grain-free grains Inflammation wheat belly Source Type: blogs
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Behavioral Health Healthy Eating Mental Health Source Type: blogs
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Health Source Type: blogs
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Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
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Celiac disease (CD) is an increasingly common chronic autoimmune disease caused by permanent gluten sensitivity that occurs in people carrying the HLA-DQ2 or HLA-DQ8. It causes both gastroenteropathy (demonstrated by duodenal biopsy) and extraintestinal pathologic conditions (Fig 1A and B). The disease is often diagnosed by the discovery of positive autoantibodies (anti –tissue transglutaminase [anti-tTG] IgA and anti–endomysial antibody [EMA] IgA) in a patient, which might trigger an intestinal biopsy that reveals villous atrophy.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Disease in a Nutshell Source Type: research
Conclusion While government groups maintain that no studies have been done to compare the health of vaccinated to unvaccinated, the reality is that several comparative studies have been completed by independent researchers in the US and in other countries. The Centers for Disease Control and Prevention refuses to conduct such studies, claiming they would be unethical to perform. In reality, these studies could easily be performed, since many educated parents choose to not vaccinate their children. The evidence is overwhelming. Studies completed in New Zealand, Germany, Africa, Great Britain and the United States have come ...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Picks Top Stories truth about vaccines vaccinated vs. unvaccinated Source Type: blogs
Conclusion While government groups maintain that no studies have been done to compare the health of vaccinated to unvaccinated, the reality is that several comparative studies have been completed by independent researchers in the US and in other countries. The Centers for Disease Control and Prevention refuses to conduct such studies, claiming they would be unethical to perform. In reality, these studies could easily be performed, since many educated parents choose to not vaccinate their children. The evidence is overwhelming. Studies completed in New Zealand, Germany, Africa, Great Britain and the United States have come ...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Picks Top Stories truth about vaccines vaccinated vs. unvaccinated Source Type: blogs
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