Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications

Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Giuseppe Murdaca, Alessandro Tonacci, Simone Negrini, Monica Greco, Matteo Borro, Francesco Puppo, Sebastiano GangemiAbstractVitamin D plays a key role in in calcium homeostasis and, thus, provides an important support in bone growth by aiding in the mineralization of the collagen matrix. However, vitamin D performs various immunomodulatory, anti-inflammatory, antioxidant and anti-fibrotic actions. Autoimmune diseases result from an aberrant activation of the immune system, whereby the immune response is directed against harmless self-antigens. Does vitamin D play a role in the pathophysiology of autoimmune diseases? And, if so, what is its role? In the last decade, researchers’ interest in vitamin D and its correlations with autoimmune diseases has considerably increased. We conducted a literature review, covering the period January 1, 2009 through March 30, 2019, in PubMed. We analyzed more than 130 studies in order to find a correlation between vitamin D levels and its effect upon several autoimmune diseases. The analysis demonstrated an inverse association between vitamin D and the development of several autoimmune diseases, such as SLE, thyrotoxicosis, type 1 DM, MS, iridocyclitis, Crohn’s disease, ulcerative colitis, psoriasis vulgaris, seropositive RA, polymyalgia rheumatica. International multicenter study could allow us to confirm the data already present in the literatu...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research

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VITAMIN B12 is an essential nutrient that keeps the nervous system functionally correctly. Lacking in the vitamin could be detrimental to one ’s health and spotting this sign in your face is a warning. What is it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 23 August 2019Source: The LancetAuthor(s): Jo Hardy, Christina Baggott, James Fingleton, Helen K Reddel, Robert J Hancox, Matire Harwood, Andrew Corin, Jenny Sparks, Daniela Hall, Doñah Sabbagh, Saras Mane, Alexandra Vohlidkova, John Martindale, Mathew Williams, Philippa Shirtcliffe, Mark Holliday, Mark Weatherall, Richard Beasley, Andrew Corin, Liz DronfieldSummaryBackgroundIn adults with mild asthma, a combination of an inhaled corticosteroid with a fast-onset long-acting β-agonist (LABA) used as reliever monotherapy reduces severe exacerbations compared with short-acting &b...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 23 August 2019Source: The LancetAuthor(s): Marc Gauthier, Sally E Wenzel
Source: The Lancet - Category: General Medicine Source Type: research
Serum and Cerebrospinal Fluid Levels of S-100β Is A Biomarker for Spinal Cord Injury; a Systematic Review and Meta-Analysis. Arch Acad Emerg Med. 2019;7(1):e19 Authors: Faridaalee G, Keyghobadi Khajeh F Abstract Introduction: There is controversy regarding the value of serum or cerebrospinal fluid (CSF) levels of S100 calcium-binding protein B (S-100B) in spinal cord injury (SCI). For reaching a general conclusion, the present meta-analysis was designed aiming to evaluate the value of serum and CSF levels of S-100B protein in detecting the presence of SCI in animal studies. Methods: An exten...
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Arch Acad Emerg Med Source Type: research
ConclusionRapid and accurate diagnosis of A-AIH may be difficult. However, timely start of immunosuppressive therapy improves prognosis and decreases number of indicated liver transplantations in children with AIH.
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
Publication date: Available online 23 August 2019Source: Pharmacological ResearchAuthor(s): Oh Yoen Kim, Ji Yeon Chung, Juhyun SongAbstractObesity is a globally widespread metabolic disorder, characterized by immoderate fat accumulation in the body. There are different types of body fats such as white adipose tissue (WAT), which stores surplus energy in the body, and brown adipose tissue (BAT) which utilize energy to produce heat during metabolism. BAT acts many beneficial functions in metabolic disorders including type 2 diabetes and obesity. Recent studies have investigated methods for promoting the fat browning process ...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: 30 October 2019Source: International Journal of Pharmaceutics, Volume 570Author(s): Marco Bellini, Mathias Walther, Roland BodmeierAbstractThe aim of this study was to evaluate the influence of tableting process parameters, i.e. turret rotation speed, pre-compaction and main compaction pressures, and their interactions on layer adhesion of bilayer tablets. The elastic recovery after compaction was used as estimation for the elasticity of the material. Three potential pharmaceutical formulations were evaluated as combinations of immediate (microcrystalline cellulose, lactose, calcium phosphate, pregelatini...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Abstract AIM: To investigate whether immune mediated diseases (IMD) are more frequent in patients with inflammatory bowel disease (IBD). METHODS: In this population based registry study, a total of 47325 patients with IBD were alive and registered in the Danish National Patient Registry on December 16, 2013. Controls were randomly selected from the Danish Civil Registration System (CRS) and matched for sex, age, and municipality. We used ICD 10 codes to identify the diagnoses of the included patients. The IBD population was divided into three subgroups: Ulcerative colitis (UC), Crohn's disease (CD) and Both t...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
CONCLUSIONS: We found no statistically significant associations between atopy and autoimmune disease, but we cannot exclude relatively small to moderate effects - protective or promotive - of atopy on autoimmune disease. PMID: 25600125 [PubMed - in process]
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Director chair, film slate and load horn. Here’s a proposal for you: If, by following the Wheat Belly lifestyle, a long list of conditions are reduced or reversed at no risk, almost no cost, reversing even chronic and potentially fatal conditions . . . does that mean that the notion of self-directed health might be on the horizon, i.e., putting control over health back in our own hands? I think it does. No, we will never implant our own defibrillators or take out our own gallbladders. But so many chronic health conditions afflicting modern humans recede that I believe that it is entirely reasonable to start talking a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle arthritis autoimmune diabetes eating disorder gluten grains Inflammation joint Weight Loss Source Type: blogs
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