New study discovers genetic changes linked to leukemia in children with Down syndrome

(University of Oxford) Researchers at the University of Oxford, in collaboration with colleagues from Hannover Medical School and Martin-Luther-University Halle-Wittenberg, have discovered the specific gene mutations that are required for the development of leukemia in children with Down syndrome.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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CONCLUSIONS: Altogether, using novel and suitable PDX models, this study indicates that RAS/MAPK pathway inhibition represents a promising strategy to improve the outcome of DS children with B-cell precursor leukemia. PMID: 32220889 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Authors: Aisyi M, Andriastuti M, Kurniati N Abstract BACKGROUND: Hyperglycaemia is a common side effect of steroid and L-asparaginase combinations, occurring mostoften during acute lymphoblastic leukemia (ALL) induction phase. To date in Indonesia, it has not been obtained dataon the incidence of hyperglycemia in children with ALL in the induction phase and how the role of combinations ofL-asparaginase and different type of steroid used. The purpose of this study is to determine the incidence of hyperglycemiain children ALL induction phase, knowing the difference between prednisone and dexamethasone (in combination...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Publication date: 16 September 2019Source: Cancer Cell, Volume 36, Issue 3Author(s): Maurice Labuhn, Kelly Perkins, Sören Matzk, Leila Varghese, Catherine Garnett, Elli Papaemmanuil, Marlen Metzner, Alison Kennedy, Vyacheslav Amstislavskiy, Thomas Risch, Raj Bhayadia, David Samulowski, David Cruz Hernandez, Bilyana Stoilova, Valentina Iotchkova, Udo Oppermann, Carina Scheer, Kenichi Yoshida, Adrian Schwarzer, Jeffrey W. Taub
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Publication date: 12 August 2019Source: Cancer Cell, Volume 36, Issue 2Author(s): Yehudit Birger, Ruth Shiloh, Shai IzraeliStudies of the mechanisms of acute leukemia transformation from a preleukemic state in humans are hampered by the absence of clinical preleukemia syndromes. In this issue of Cancer Cell, Labuhn et al. provide a functional genomics view on the leukemic evolution from congenital preleukemia in children with Down syndrome.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Publication date: Available online 11 July 2019Source: Cancer CellAuthor(s): Maurice Labuhn, Kelly Perkins, Sören Matzk, Leila Varghese, Catherine Garnett, Elli Papaemmanuil, Marlen Metzner, Alison Kennedy, Vyacheslav Amstislavskiy, Thomas Risch, Raj Bhayadia, David Samulowski, David Cruz Hernandez, Bilyana Stoilova, Valentina Iotchkova, Udo Oppermann, Carina Scheer, Kenichi Yoshida, Adrian Schwarzer, Jeffrey TaubSummaryMyeloid leukemia in Down syndrome (ML-DS) clonally evolves from transient abnormal myelopoiesis (TAM), a preleukemic condition in DS newborns. To define mechanisms of leukemic transformation, we combin...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
(University of Oxford) Researchers at the University of Oxford, in collaboration with colleagues from Hannover Medical School and Martin-Luther-University Halle-Wittenberg, have discovered the specific gene mutations that are required for the development of leukaemia in children with Down's syndrome.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Publication date: Available online 29 March 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): David Tweats, David A. Eastmond, Anthony M. Lynch, Azeddine Elhajouji, Roland Froetschl, Micheline Kirsch-Volders, Francesco Marchetti, Kenichi Masumura, Francesca Pacchierotti, Maik SchulerAbstractAneuploidy is regarded as a hallmark of cancer, however, its role is complex with both pro- and anti-carcinogenic effects evident. In this IWGT review, we consider the role of aneuploidy in cancer biology; cancer risk associated with constitutive aneuploidy; rodent carcinogenesis with known chemica...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
Adauto Lima Cardoso1, Bruno Evaristo de Almeida Fantinatti1, Natália Bortholazzi Venturelli1, Bianca de Oliveira Carmello1, Rogério Antonio de Oliveira2 and Cesar Martins1* 1Integrative Genomics Laboratory, Department of Morphology, Institute of Biosciences, São Paulo State University – Universidade Estadual Paulista, Botucatu, Brazil 2Department of Biostatistics, Institute of Biosciences, São Paulo State University – Universidade Estadual Paulista, Botucatu, Brazil Supernumerary B chromosomes are dispensable elements found in several groups of eukaryotes, and their impact...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In conclusion, we have shown the safety and efficacy of Vemurafenib in a pediatric patient with DS affected by PXA. Ethics Statement This study was carried out in accordance with the recommendations of the Internal Review Board of the Bambino Gesù Children's Hospital with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Internal Review Board of the Bambino Gesù Children's Hospital. Informed Consent The authors declare that written informed consent was obtained from the pat...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
B-acute lymphoblastic leukemia (B-ALL) in patients with Down syndrome (DS) has a worse prognosis than non-DS B-ALL. However, associated cytogenetic alterations may alter the prognosis. Here we discuss a 13-year-old female with DS presenting with leg pain, fevers, white blood cell count 12.8 k/ul, hemoglobin 7.7 g/dL, platelets 31 k/ul, and 60.9% blasts on differential. Flow cytometry identified B-lymphoblasts (positive for CD19, cytoCD79a, cytoCD22, CD34, CD10, TdT, and CD45 (dim)) and bone marrow biopsy demonstrated sheets of B-lymphoblasts.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
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