Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma

ConclusionsNanoencapsulation of MLT was crucial for the selective antitumoral activity against U87MG.In vivo evaluation confirmed nose-to-brain delivery of MLT mediated by nanoparticles, highlighting the formulation as a suitable approach to improve glioblastoma therapy.

Source: Pharmaceutical Research - June 30, 2019 Category: Drugs & Pharmacology Source Type: research