Pharmacological safety of Plinia cauliflora (Mart.) Kausel in rabbits

Publication date: Available online 28 June 2019Source: Toxicology ReportsAuthor(s): Rhanany Alan Calloi Palozi, Lucas Pires Guarnier, Paulo Vitor Moreira Romão, Samara Requena Nocchi, Carlos Calixto dos Santos, Emerson Luiz Botelho Lourenço, Denise Brentan Silva, Francielly Mourão Gasparotto, Arquimedes GasparottoAbstractFruit peels of Plinia cauliflora (Mart.) Kausel are widely used in Brazilian traditional medicine, but no studies have proved the safety of its pharmacological effects on the respiratory, cardiovascular, and central nervous systems. The present study assessed the safety pharmacology of P. cauliflora in New Zealand rabbits. First, an ethanol extract (EEPC) was selected for the pharmacological experiments and chemical characterization. Then, different groups of rabbits were orally treated with EEPC (200 and 2000 mg/kg) or vehicle. Acute behavioral and physiological alterations in the modified Irwin test, respiratory rate, arterial blood gas, and various cardiovascular parameters (i.e., heart rate, blood pressure, and electrocardiography) were evaluated. The main secondary metabolites that were identified in EEPC were ellagic acid, gallic acid, O-deoxyhexosyl quercetin, and the anthocyanin O-hexosyl cyanidin. No significant behavioral or physiological changes were observed in any of the groups. None of the doses of EEPC affected respiratory rate or arterial blood gas, with no changes on blood pressure or electrocardiographic parameters. The present study sh...
Source: Toxicology Reports - Category: Toxicology Source Type: research