Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation

Lewy body dementia (LBD) is a major public health problem worldwide. Prevalence of Lewy body dementia (LBD) is second only to Alzheimer's disease (AD) among people with neurodegenerative dementia.1 LBD cause earlier mortality,2 earlier nursing home admissions, poorer quality-of-life, higher costs,3 more frequent falls, and more caregivers ’ burden than AD. LBD include two overlapping clinical syndromes, dementia with Lewy bodies (DLB) and Parkinson's disease (PD) dementia (PDD). They cause more frequent and more intense neuropsychiatric symptoms including visual hallucinations, delusions, agitation, and depression than AD.

Source: The American Journal of Geriatric Psychiatry - June 23, 2019 Category: Geriatrics Authors: Anto P. Rajkumar, Gholamreza Bidkhori, Saeed Shoaie, Emily Clarke, Hamilton Morrin, Abdul Hye, Gareth Williams, Clive Ballard, Paul Francis, Dag Aarsland Tags: Regular Research Article Source Type: research