Altered Dietary Selenium Influences Brain Iron Content and Behavioural Outcomes.

Altered Dietary Selenium Influences Brain Iron Content and Behavioural Outcomes. Behav Brain Res. 2019 Jun 15;:112011 Authors: Sharma SK, Bansal MP, Sandhir R Abstract Selenium (Se) is an essential micronutrient that provides antioxidant defence through selenoproteins, but at high concentrations, deleterious effects have been reported. The present study examines the antioxidant response in brain regions and behavioural functions in mice under various dietary Se paradigms; Se-deficient, Se-adequate and Se-excess. Se levels were found to be reduced in the cortex and hippocampus of Se-deficient animals, whereas no change was observed in animals on Se-excess diet. In the hippocampus, iron (Fe) levels increased in both Se-deficient and Se-excess animals. Moreover, in Se-deficient animals, Fe levels increased in cortex also. Interestingly, Se content in the hair positively correlated with the dietary Se intake. Total and Se-dependent glutathione peroxidase activity decreased in the cortex, hippocampus and cerebellum of animals on Se-deficient diet. On the other hand, the activity of these enzymes decreased in the cortex of animals on Se-excess diet. Further, lipid peroxidation was increased in the cortex of animals on Se-deficient diet and in hippocampus of animals on Se-excess diet. Cognitive functions assessed by open field, Morris water maze and Y-maze tests revealed deficits in Se-deficient state. However, in Se-excess state cognitive ...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research