Whole-genome comparative analysis of Campylobacter jejuni strains isolated from patients with diarrhea in northeastern Poland

ConclusionsCampylobacter jejuni ST50, ST51 and ST257 are among the top ten of STs isolated in Europe. WGS revealed diversity of serotypes and LOS classes in ST50 strains, that deserves further clinical and epidemiological investigations as it might be related to a risk of post-infectious neurological sequels such as Guillain-Barr é syndrome. Additionally, the results implicate lower pathogenic potential and distinct transmission chains or reservoirs forC. jejuni ST51 isolates responsible for campylobacteriosis in northeastern Poland.
Source: Gut Pathogens - Category: Microbiology Source Type: research

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Authors: Maly M, Willandt B, Nulens E, Snauwaert C PMID: 31314200 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
In this study, FYC and its main components dramatically suppressed the infiltration of inflammatory cells, reduced the production of IL-1β, TNF-α, and MCP-1, and elevated the IL-10 level to varying degrees. We also found that FYC and its main components inhibited the expression of BAX induced by infection and increased the expression of Bcl-2. FYC, GA, EA, and SY could also block the activation of the NF-κB pathway. Finally, we found that the phosphorylation of JNK could be decreased by FYC, GA, and SY. FYC and its main components exhibit anti-inflammatory effect on a pathogen-induced PID model by regulati...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
America ’s strong economic growth and high living standards were built on our relatively smaller government. U.S. per capita income is higher than nearly all major countries and our government spending is still somewhat less.However, America ’s lower-spending advantage has diminished. TheOECD publishes data on total federal-state-local government spending as a percentage of GDP for its member countries. The chart shows spending for the United States and for the simple average of 30 OECD countries which have data back to 1995. These are high-income countries such as Canada, Germany, and Japan.The chart shows tha...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Conclusions: GBS in Indian population from northwest India showed peculiar age, seasonal distribution and high frequency of both AIDP and axonal subtypes. Both, axonal and demyelinating subtypes shared common clinical features and had good prognosis. PMID: 31309800 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
The objective of the current study was to provide thermal dependent evolution profile for mass loss and pyrolysis gas, in addition to the partial quantification of the waxy products. The polymer degradation was first characterized by thermogravimetric analysis. Many parameters were studied such as final temperature, heating rate, flow rate and the presence or not of a lid on the crucible. The slow pyrolysis of PET was then performed in a horizontal tubular reactor at 5 °C/min. The pyrolysis products were analysed, focusing especially on gaseous and waxy fractions. The gas emitted was monitored online by µ-...
Source: Journal of Analytical and Applied Pyrolysis - Category: Chemistry Source Type: research
Conclusions: In Europe, 61-97% of women have a dietary iron intake below 15 mg/day. This contributes to a low iron status in many women. We need common European standardized dietary methods, uniform dietary reference values, and uniform statistical methods to perform intercountry comparisons. PMID: 31312532 [PubMed]
Source: Journal of Nutrition and Metabolism - Category: Nutrition Tags: J Nutr Metab Source Type: research
Abstract The Campylobacter genus is a large and diverse group of Gram-negative bacteria that are known to colonize humans and other mammals, birds, reptiles, and shellfish. While it is now recognized that several emerging Campylobacter species can be associated with human disease, two species, C. jejuni and C. coli, are responsible for the vast majority of bacterial gastroenteritis in humans worldwide. Infection with C. jejuni, in particular, has also been associated with a number of extragastrointestinal manifestations and autoimmune conditions, most notably Guillain-Barré syndrome. The antimicrobial drugs...
Source: Advances in Applied Microbiology - Category: Microbiology Authors: Tags: Adv Appl Microbiol Source Type: research
Campylobacter is a major causative agent of bacterial gastroenteritis worldwide [1]. In the Netherlands, the annual incidence of Campylobacter gastroenteritis was estimated at circa 5.6 cases/1000 inhabitants in 2009, and is the foodborne bacterium most frequently causing hospitalization [2]. Guillain –Barré syndrome, reactive arthritis, irritable bowel syndrome, and inflammatory bowel disease, are among the possible sequelae of Campylobacter clinical infection. Altogether, Campylobacter is the foodborne pathogen with the highest human disease burden and the second highest economic costs in th e Netherlands [3].
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Guillain Barré Syndrome is induced in Non-Obese Diabetic (NOD) mice following Campylobacter jejuni infection and is exacerbated by antibiotics. J Autoimmun. 2016 Dec 08;: Authors: St Charles JL, Bell JA, Gadsden BJ, Malik A, Cooke H, Van de Grift LK, Kim HY, Smith EJ, Mansfield LS Abstract Campylobacter jejuni is a leading cause of bacterial gastroenteritis linked to several serious autoimmune sequelae such as the peripheral neuropathies Guillain Barré syndrome (GBS) and Miller Fisher syndrome (MFS). We hypothesized that GBS and MFS can result in NOD wild type (WT) mice or their congenic...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
Discussion Guillian-Barré syndrome (GBS) is an acquired, acute, inflammatory, demyelinating polyneuropathy. It is the most common cause of acute and subacute flaccid paralysis in children. GBS causes about 0.4-1.3 cases per 100,000 persons/year in children. It can occur in any age group and the incidence increases among all age groups until a peak in the 50s. Both genders are affected and there may be a slight increase in males. GBS usually occurs 2-4 weeks after a prodromonal gastroenteritis or respiratory illness. It is most often associated with Campylobacter jejunae, Haemophilus infuenza, Mycoplasma pneumoniae,...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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