Characterization of a Mouse Model of Hypereosinophilia-Associated Heart Disease.

Characterization of a Mouse Model of Hypereosinophilia-Associated Heart Disease. Am J Physiol Heart Circ Physiol. 2019 Jun 14;: Authors: Prows DR, Klingler A, Gibbons WJ, Homan SM, Zimmermann N Abstract Hypereosinophilic syndrome is characterized by sustained and marked eosinophilia leading to tissue damage and organ dysfunction. Morbidity and mortality occur primarily due to cardiac and thromboembolic complications. Understanding the cause and mechanism of disease would aid in the development of targeted therapies with greater efficacy and fewer side effects. We discovered a spontaneous mouse mutant in our colony with a hypereosinophilic phenotype. Mice develop peripheral blood eosinophilia, infiltration of lungs, spleen and heart by eosinophils, and extensive myocardial damage and remodeling. This ultimately leads to heart failure and premature death. Histopathologic assessment of the hearts revealed a robust inflammatory infiltrate composed primarily of eosinophils and B-lymphocytes, associated with myocardial damage and replacement fibrosis, consistent with eosinophilic myocarditis (EM). In many cases, hearts showed dilatation and thinning of the right ventricular wall, suggestive of an inflammatory dilated cardiomyopathy. Most mice showed atrial thrombi, which often filled the chamber. Protein expression analysis revealed overexpression of chemokines and cytokines involved in innate and adaptive immunity including IL-4, eotaxin and RANTES. Disease c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research

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CONCLUSIONS: For RCS, HRQOL in PD+HD patients was better than that in HD and comparable with that in PD patients, whereas the PCS, MCS, and KDCS HRQOL scores of PD+HD patients were comparable with those of HD and PD patients. PMID: 32063200 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Authors: Chionh CY, Clementi A, Poh CB, Finkelstein FO, Cruz DN Abstract Heart failure (HF) is a major cause of morbidity and mortality. Extracorporeal (EC) therapy, including ultrafiltration (UF) and haemodialysis (HD), peritoneal dialysis (PD) and peritoneal ultrafiltration (PUF) are potential therapeutic options in diuretic-resistant states. This systematic review assessed outcomes of PD and compared the effects of PD to EC. A comprehensive search of major databases from 1966 to 2017 for studies utilising PD (or PUF) in diuretic-resistant HF was conducted, excluding studies involving patients with end-stage kidn...
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Publication date: Available online 19 February 2020Source: Journal of Cardiology CasesAuthor(s): Chiaki Goten, Soichiro Usui, Takuto Hamaoka, Tomoya Harada, Oto Inoue, Hirofumi Okada, Shin-ichiro Takashima, Takeshi Kato, Hisayoshi Murai, Kenji Sakata, Hiroshi Furusho, Masa-aki Kawashiri, Masayuki TakamuraAbstractThe prognosis of pulmonary arterial hypertension (PAH) has significantly improved over the past two decades due to advances in medications, including pulmonary vasodilators. However, the side effects of these drugs remain problematic in some patients. A 51-year-old woman with chronic hepatitis C was diagnosed with ...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
ConclusionThe final results of this study showed that there was no significant difference between the four study groups and arrhythmia status. Therefore, f-QRS was not introduced as an independent predictor of arrhythmia in patients with acute MI.
Source: Indian Heart Journal - Category: Cardiology Source Type: research
ConclusionsCardiac rehabilitation programs containing exercise may provide broader cardiovascular benefits compared to those without exercise.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 18 February 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Andrea De Gasperi, Gregorio Spagnolin, Martina Ornaghi, Laura Petrò, Gianni BiancofioreAbstractNew and extended indications, older age, higher cardiovascular risk, and the long-standing cirrhosis - associated complications mandate specific skills for an appropriate preoperative assessment of the LT candidate. The incidence of cardiac diseases (dysrhythmias, cardiomyopathies, coronary artery disease, valvular heart disease) are increasing among LT recipients: however, no consensus exists among cli...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
Conclusion: Self-management behaviors and HrQoL of CHD patients in Chinese communities were inadequate. There is a positive correlation between self-management behaviors and HrQoL among CHD patients in Chinese community settings. Therefore, it is critical to improve self-management behaviors and HrQoL of CHD patients in Chinese communities.Impact statement: Self-management behaviors were found to positively influence on HrQoL among CHD patients in Chinese community settings. It is necessary to develop the nursing intervention on self-management behaviors to enhance the HrQoL of CHD patients in Chinese communities. PMID...
Source: Contemporary Nurse - Category: Nursing Tags: Contemp Nurse Source Type: research
This article provides a general overview of each imaging modality and practical guidance for early detection and monitoring of cardiotoxicity.Areas covered: Cardiovascular imaging modalities and cardiac biomarkers for monitoring of cardiac function and early detection of drug-induced myocardial dysfunction in drug development.Expert opinion: Some new drugs especially in the oncology field, can cause myocardial dysfunction. Depending on the strength of pre-clinical or clinical data, CV imaging modalities and cardiac biomarkers play an important role in the early detection and mitigation plans for such drugs during their dev...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Gynecology, Oncology, News, Source Type: news
AbstractIn humans, it is acknowledged that dilated cardiomyopathy is also caused by infection-induced myocarditis. To evaluate whether the occurrence of lesions of dilated cardiomyopathy in cattle may be triggered by myocarditis, an adult Holstein-Friesian dairy cow which showed dilated cardiomyopathy associated with myocarditis was examined by histopathology. Traumatic pericarditis or idiopathic congestive heart failure was clinically suspected, and the animal was culled because of unfavorable prognosis. Histopathological examination revealed an intrinsic cardiomyopathic lesion that overlapped with myocarditis. Cardiomyoc...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
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