Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1 α -mediated regulation of apoptosis and autophagy

Conclusion: HIF-1α and HDAC4 may mediate the interaction between p53 and RAS signaling to actively control ovarian cancer cisplatin resistance through dysregulation of apoptosis and autophagy. Targeting HDAC4, HIF-1α and CREBZF may be considered in treatment of ovarian cancer with p53 and RAS mutations.

Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Xiaofei Zhang, Zihao Qi, Huijing Yin, Gong Yang Tags: Research Paper Source Type: research