Prevalence and Clinical Significance of Antineutrophil Cytoplasmic Antibodies in North American Patients with Idiopathic Pulmonary Fibrosis.

CONCLUSIONS: ANCA-antibody positivity is uncommon in North American patients with IPF and not associated with baseline disease severity or transplant-free survival; however, a significant proportion of MPO-positive IPF patients develop clinical vasculitis.; Abbreviation List: ANCA: Antineutrophil cytoplasmic antibodies; CLIA: Clinical Laboratory Improvement Amendments; CT: Computed tomography; CTD: Connective tissue disease; DLCO: Diffusing capacity of the lung for carbon monoxide; FEV1: Forced expiratory volume in one second; FVC: Forced vital capacity; HR: Hazard ratio; ILD: Interstitial lung disease; IPF: Idiopathic pulmonary fibrosis; IPAF: Interstitial pneumonia with autoimmune features; MPA: microscopic polyangiitis; MPO: Myeloperoxidase; PR3: Proteinase 3; TLC: Total lung capacity; UC: University of Chicago; UCSF: University of California San Francisco; UIP: Usual interstitial pneumonia.
PMID: 31181198 [PubMed - as supplied by publisher]

Source: Chest - June 6, 2019 Category: Respiratory Medicine Authors: Liu GY, Ventura IB, Achtar-Zadeh N, Elicker BM, Jones KD, Wolters PJ, Collard HR, Adegunsoye A, Strek ME, Ley B Tags: Chest Source Type: research