Identification of the key pathways and genes involved in HER2-positive breast cancer with brain metastasis.

CONCLUSION: Our study suggests that the five hub genes (PHLPP1, UBC, ACACB, TGFB1, and ACTB) are associated with HER2+BC with BM. The GSEA analysis revealed that the ribosomal pathway seems to play a very important role in the pathogenesis of HER2+BC with BM.
PMID: 31178227 [PubMed - as supplied by publisher]

Source: Pathology, Research and Practice - May 31, 2019 Category: Pathology Authors: Lu X, Gao C, Liu C, Zhuang J, Su P, Li H, Wang X, Sun C Tags: Pathol Res Pract Source Type: research