Impaired AMPK ‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury.

Impaired AMPK‑CGRP signaling in the central nervous system contributes to enhanced neuropathic pain in high‑fat diet‑induced obese rats, with or without nerve injury. Mol Med Rep. 2019 Jun 06;: Authors: Guo X, Tao X, Tong Q, Li T, Dong D, Zhang B, Zhao M, Song T Abstract Obesity is associated with increased sensitivity to pain, including neuropathic pain, but the precise mechanisms are not fully understood. Recent evidence has revealed that AMP‑activated protein kinase (AMPK) in the central nervous system (CNS) regulates the neuropeptide calcitonin gene‑related peptide (CGRP), a principal neurotransmitter of the class C nerve fiber, which serves an important role in initiating and maintaining neuropathic pain. AMPK has been demonstrated to be downregulated in the CNS in obesity. The present study hypothesized that obesity may lead to increased sensitivity to neuropathic pain by downregulating AMPK and upregulating CGRP expression levels in the CNS. Sprague‑Dawley rats consuming a high‑fat diet (HF) for 12 weeks developed obesity; they exhibited significantly decreased levels of phospho (p)‑AMPK and increased CGRP expression levels in the spinal cord (SC) and dorsal root ganglion (DRG), respectively, compared with rats consuming a low‑fat (LF) diet. HF‑fed rats that underwent spared nerve injury (SNI) also exhibited lower p‑AMPK and higher CGRP expression levels in the SC and DRG, compared with the corresponding LF‑diet rats. T...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Related Links:

The migration of leukocytes into the CNS drives the neuropathology of multiple sclerosis (MS). It is likely that this penetration utilizes energy resources that remain to be defined. Using the experimental autoimmune encephalomyelitis (EAE) model of MS, we determined that macrophages within the perivascular cuff of postcapillary venules are highly glycolytic, as manifested by strong expression of lactate dehydrogenase A (LDHA), which converts pyruvate to lactate. These macrophages expressed prominent levels of monocarboxylate transporter-4 (MCT-4), which is specialized in the secretion of lactate from glycolytic cells. The...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ABSTRACT Duguetia furfuracea (Annonaceae) is a shrub found in the Brazilian Cerrado that is used in popular medicine as an antirheumatic, for wound healing, treatment of kidney pain and against pediculosis. The aim of this study was to analyze the extraction of leaves of Duguetia furfuracea, using supercritical CO2, ethanol and hexane as solvents. For the supercritical extraction, an experimental planning 23 with triplicates of the central point was used to evaluate the effects of temperature (313-333 K), pressure (15-23 MPa) and volumetric flow rate (3-6 mL min-1) on the extraction yield, total phenolic content and antiox...
Source: Brazilian Journal of Chemical Engineering - Category: Chemistry Source Type: research
[UN] An estimated 820 million people did not have enough to eat in 2018, up from 811 million in the previous year, which is the third year of increase in a row. This underscores the immense challenge of achieving the Sustainable Development Goal of Zero Hunger by 2030, says a new edition of the annual The State of Food Security and Nutrition in the World report released today.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Thomson Reuters Foundation] Our food systems are distorted, and unless bolder actions are taken soon to fix them, humanity is at grave risk of increasing hunger, obesity and diet-related illnesses. It is a stark warning, but one that must be heeded if all countries are to fulfil their commitment to achieve the Sustainable Development Goal number 2 - eradicating hunger and all forms of malnutrition.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Conclusion: healthy eating is conceptualized by what adolescents consider good or bad for their health, but this evaluation is not directly related to their eating practices. The contradictions between knowledge and practice are evidenced in order to guide propositional interventions with this population group.RESUMEN Objetivo: describir las representaciones sociales sobre alimentaci ón sana y analizar las relaciones establecidas con la salud. Método: estudio exploratorio y descriptivo, con abordaje cualitativo que aplicó la Teoría de las Representaciones Sociales. Se realizó una entrevis...
Source: Texto e Contexto - Enfermagem - Category: International Medicine & Public Health Source Type: research
Entire medical record, lawsuit, etc... is here: Case 10: Shortness of Breath – medmalreviewer Med mal cases require a HIPAA waiver so the records are available to the public, this site publishes them. TL;DR 33 year old woman seen in ED for respiratory distress. Tons of comorbidities. Given Dilaudid for pain. Results don't show any acute emergency (depending on who you ask). Discharged from the ED. Sitting in ED lobby... Medical Malpractice Case
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Educational Quizzes and Case Studies Forum Source Type: forums
Publication date: Available online 15 July 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Insiyyah Patanwala, Chensi Ouyang, Matthew Fisk, Georgine LamvuAbstractStudy ObjectiveTo compare the amount of opioids (tablets and morphine milligram equivalents-MME) prescribed by physicians and used by patients, after benign gynecologic surgery.DesignProspective Cohort StudySettingTertiary Center- Main Hospital Operating Room and Outpatient Surgery CenterPatientsWomen undergoing benign gynecologic surgeryInterventionsMajor and minor gynecologic surgeriesMeasurementsThe surgery groups were: 1) minor laparoscopy (Mino...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusion: The high prevalence of musculoskeletal pain demonstrates the need for strategies aimed at preventing this aggravation still in the academic setting.RESUMEN Objetivo: Verificar la prevalencia y factores asociados con el dolor musculoesquel ético en estudiantes de pregrado del área sanitaria. Método: Estudio transversal, realizado en con estudiantes de pregrado de una universidad del Sur de Brasil en el período de abril a julio de 2017. Se empleó el cuestionario de caracterización de los estudiantes y la versión brasileña del Standardized Nordic Questionnair...
Source: Revista da Escola de Enfermagem da USP - Category: Nursing Source Type: research
Regardless of how much genetic risk someone has, a good diet, adequate exercise, limiting alcohol and not smoking made dementia less likely
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
More News: Back Pain | Brain | Diets | Eating Disorders & Weight Management | Ganglions | Molecular Biology | Neurology | Nutrition | Obesity | Pain | Spinal Cord Injury | Study