Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis

Publication date: Available online 6 June 2019Source: The Lancet PsychiatryAuthor(s): Toshi A Furukawa, Andrea Cipriani, Philip J Cowen, Stefan Leucht, Matthias Egger, Georgia SalantiSummaryBackgroundDepression is the single largest contributor to non-fatal health loss worldwide. Second-generation antidepressants are the first-line option for pharmacological management of depression. Optimising their use is crucial in reducing the burden of depression; however, debate about their dose dependency and their optimal target dose is ongoing. We have aimed to summarise the currently available best evidence to inform this clinical question.MethodsWe did a systematic review and dose-response meta-analysis of double-blind, randomised controlled trials that examined fixed doses of five selective serotonin reuptake inhibitors (SSRIs; citalopram, escitalopram, fluoxetine, paroxetine, and sertraline), venlafaxine, or mirtazapine in the acute treatment of adults (aged 18 years or older) with major depression, identified from the Cochrane Central Register of Controlled Trials, CINAHL, Embase, LILACS, MEDLINE, PsycINFO, AMED, PSYNDEX, websites of drug licensing agencies and pharmaceutical companies, and trial registries. We imposed no language restrictions, and the search was updated until Jan 8, 2016. Doses of SSRIs were converted to fluoxetine equivalents. Trials of antidepressants for patients with depression and a serious concomitant physical illness were excluded. The main outcomes were...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research

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ConclusionsThe therapeutic effect of acupuncture and moxibustion by soothing liver and regulating mind can obviously improve the quality of life of depression elders.
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
Conclusion: Experiences of being sexually harassed correlate among adolescents with high social anxiety but also with high self-esteem. Sexual harassment among adolescents may partly be explained as inept ways of showing interest, but it may nevertheless have detrimental effects on the well-being of the those subjected to it. PMID: 31311376 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
ConclusionsThe findings suggest the need for a more nuanced perspective on maintaining cool status during adolescence that considers both its risks and benefits.
Source: Journal of Adolescence - Category: Child Development Source Type: research
CONCLUSION: Make-up therapy to improve the symmetry of facial appearance could afford a noninvasive and low-cost treatment for patients with facial nerve palsy, especially in terms of patient quality of life and psychological condition. PMID: 31307215 [PubMed - in process]
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
In conclusion, feeding can affect the pharmacokinetics of VLZ in the dog.
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
Publication date: Available online 17 July 2019Source: Artificial Intelligence in MedicineAuthor(s): Xiaowei Li, Xin Zhang, Jing Zhu, Wandeng Mao, Shuting Sun, Zihan Wang, Chen Xia, Bin HuAbstractThe diagnosis of depression almost exclusively depends on doctor-patient communication and scale analysis, which have the obvious disadvantages such as patient denial, poor sensitivity, subjective biases and inaccuracy. An objective, automated method that predicts clinical outcomes in depression is essential for increasing the accuracy of depression recognition and treatments. This paper aims at better recognizing depression using...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Conclusion: There is high prevalence of depression among TB patients. It is more common in males and alcoholics. Patients who are in the first four months of the treatment are more likely to have depression. There should be regular screening of the patients with TB for psychiatric illness during the course of the treatment for better treatment compliance and outcome. PMID: 31313544 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: Poisoning was predominant in unmarried young males from lower economic class. The most common type of poisoning was suicidal, route was oral and agent was chemicals. Vomiting and pain in abdomen were the most common clinical features. Chemical poisoning was highly associated with renal failure and aspiration chemical pneumonitis requiring ventilator support and high mortality. Chemical agent of poisoning, Intravenous route of poisoning, requirement of mechanical ventilation, duration of hospital stay were significantly associated with mortality. PMID: 31311221 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: Our findings show that disability assessment late in the first week after onset of stroke using NIHSS accurately forecast outcome at one month after onset of stroke. The MMSE too is not expected to change at 1 month. Those with aphasia are expected to have greater disability. Based on or study we recommend that stroke patients should be assessed with NIHSS and MMSE before discharge, to explain the prognosis of the patient. Also more intense counselling on controlling blood pressure and diabetes as well as abstinence from smoking should be undertaken routinely. PMID: 31309796 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: While there is some evidence of compromised frontoparietal structure and function in adolescent cannabis use, it remains unclear whether the observed effects are specifically attributable to adolescent onset of use or general cannabis use-related factors such as depressive symptoms. The relative contribution of adolescent onset of cannabis use and use chronicity will have to be more comprehensively examined in prospective, longitudinal studies with more rigorous measures of cannabis use (dosage, exposure, dependence, constituent compounds such as the relative cannabinoid levels). PMID: 31311489 [PubMed - a...
Source: Journal of Dual Diagnosis - Category: Addiction Tags: J Dual Diagn Source Type: research
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