Brain F18 FDG PET CT in patients with Anti-LGI1 encephalitis

Conclusions: Anti-LGI1 encephalitis is a subtype of autoimmune encephalitis that results from antibodies targeted at leucine rich glioma inactivated 1 (LGI1) protein. This autoantigen is secreted from neuronal proteins and acts as a ligand for ADAM22 and ADAM23 which are epilepsy-related proteins (1). Early intervention improves long term outcomes (2). Patients may show cognitive abnormality and seizures (3). MRI results usually reveal medial temporal hyperintensity (4). Less is known regarding the F18 FDG PET evaluation of the patients. Herein, we present the results of 47 brain clusters based on FDG PET scans compared to 50 normal controls. Considering the abnormal signal in medial temporal areas on MRI, our results show that these areas are hypermetabolic. On the other hand frontal and cingulated areas show hypometabolic activity. These results provide better understanding of the nature of this neurologic disease and may help us diagnose patients at onset of disease which will allow us to intervene earlier.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research