Impact of thyroid function on standardized uptake values in reference organs on 18F-FDG PET/CT

This study aims at whether thyroid function has an effect on the 18F-FDG uptake in these reference organs on 18F-FDG PET/CT imaging. Materials and Methods: A total of 69 patients were included in this study for retrospective analysis. All of these patients had a thyroidectomy history,30of 69 patients were undergoing thyroid hormone replacement therapy,39 of 69 patients were not. All patients fasted for at least 6-8 h before PET-CT imaging and their fasting blood glucose levels were within the normal range. Image acquisition was performed after intravenous administration of 18F-FDG. Two groups were defined according to the thyroid function (TSH,FT3,FT4). Hypothyroidism group(n=39) and hyperthyroidism group(n=30). For all patients, we placed regions of interest (ROIs) on the right hepatic lobe, mediastinal blood pool and erector spinae muscle images and calculated the mean standardized uptake value (SUVmean) on an 18F- FDG PET scan. We statistically compared the SUVmean of above organs measured from hypothyroidism group and the hyperthyroidism group. Results: The average liver SUVmean values were calculated as 2.51±0.41, in the hypothyroidism group and 2.30±0.39, respectively, in the hyperthyroidism group. The average mediastinal blood pool SUVmean values were calculated as 0.73±0.12 , in the hypothyroidism group and 0.86±0.19, respectively, in the hyperthyroidism group. The average erector spinae muscle SUVmean values were calculated as 1.73±...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine (GCS) Posters Source Type: research

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Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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Source: Drug Metabolism Reviews - Category: Drugs & Pharmacology Tags: Drug Metab Rev Source Type: research
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Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
uesta A, Santos-Ocaña C, Hmadcha A, Soria B, Martín F, Gauthier BR, Martin-Montalvo A Abstract An inverse correlation between thyroid hormone levels and longevity has been reported in several species and reduced thyroid hormone levels have been proposed as a biomarker for healthy aging and metabolic fitness. However, hypothyroidism is a medical condition associated with compromised health and reduced life expectancy. Herein, we show, using wild-type and the Pax8 ablated model of hypothyroidism in mice, that hyperthyroidism and severe hypothyroidism are associated with an overall unhealthy status and ...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
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Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research
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Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
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Source: Interdisciplinary Sciences, Computational Life Sciences - Category: Bioinformatics Source Type: research
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Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
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Source: Journal of Nutrition and Metabolism - Category: Nutrition Tags: J Nutr Metab Source Type: research
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