Impact of thyroid function on standardized uptake values in reference organs on 18F-FDG PET/CT

This study aims at whether thyroid function has an effect on the 18F-FDG uptake in these reference organs on 18F-FDG PET/CT imaging. Materials and Methods: A total of 69 patients were included in this study for retrospective analysis. All of these patients had a thyroidectomy history,30of 69 patients were undergoing thyroid hormone replacement therapy,39 of 69 patients were not. All patients fasted for at least 6-8 h before PET-CT imaging and their fasting blood glucose levels were within the normal range. Image acquisition was performed after intravenous administration of 18F-FDG. Two groups were defined according to the thyroid function (TSH,FT3,FT4). Hypothyroidism group(n=39) and hyperthyroidism group(n=30). For all patients, we placed regions of interest (ROIs) on the right hepatic lobe, mediastinal blood pool and erector spinae muscle images and calculated the mean standardized uptake value (SUVmean) on an 18F- FDG PET scan. We statistically compared the SUVmean of above organs measured from hypothyroidism group and the hyperthyroidism group. Results: The average liver SUVmean values were calculated as 2.51±0.41, in the hypothyroidism group and 2.30±0.39, respectively, in the hyperthyroidism group. The average mediastinal blood pool SUVmean values were calculated as 0.73±0.12 , in the hypothyroidism group and 0.86±0.19, respectively, in the hyperthyroidism group. The average erector spinae muscle SUVmean values were calculated as 1.73±...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrine (GCS) Posters Source Type: research

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Authors: Halczuk KM, Boguszewska K, Urbaniak SK, Szewczuk M, Karwowski BT Abstract The thyroid is not necessary to sustain life. However, thyroid hormones (TH) strongly affect the human body. Functioning of the thyroid gland affects the reproductive capabilities of women and men, as well as fertilization and maintaining a pregnancy. For the synthesis of TH, hydrogen peroxide (H2O2) is necessary. From the chemical point of view, TH is a reactive oxygen species (ROS) and serves as an oxidative stress (OS) promoter. H2O2 concentration in the thyroid gland is much higher than in other tissues. Therefore, the thyroid is...
Source: The Yale Journal of Biology and Medicine - Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research
Ivo Iavicoli Thyroid diseases are characterized by a wide range of physical and mental symptoms that can affect biological function, emotional and social life of patients. However, their impact on work functioning is not yet fully understood. Therefore, this review aims to address the way in which thyroid diseases can affect occupational outcomes, i.e., the employment rate, sick leave, working capacity and work income of patients. A systematic review of Pubmed, Scopus and ISI Web of Knowledge databases has been performed. Although it is not possible to extrapolate precise data for benign pathologies, about a third of ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
ConclusionMany experimental studies suggest a link between hyperthyroidism/hypothyroidism and BC. We were able to demonstrate an epidemiological association between thyroiditis and an increased BC risk. This shows the need for close monitoring for BC in women with thyroiditis.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
SummaryCytotoxic T lymphocyte-associated antigen-4 (CTLA-4), the first immune checkpoint to be targeted clinically, has provided an effective treatment option for various malignancies. However, the clinical advantages associated with CTLA-4 inhibitors can be offset by the potentially severe immune-related adverse events (IRAEs), including autoimmune thyroid dysfunction. To investigate the candidate genes and signaling pathways involving in autoimmune thyroid dysfunction related to anti-CTLA-4 therapy, integrated differentially expressed genes (DEGs) were extracted from the intersection of genes from Gene Expression Omnibus...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
ConclusionsBTMs help us to better understand mechanisms of the impact of hormonal disorders and their treatment on bone metabolism. However, it is unknown whether BTMs may be used to monitor the effect of their treatments on bone in the clinical practice.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
CONCLUSIONS: Immune checkpoint inhibitor-associated thyroiditis is a distinct clinical entity. Mechanisms underlying aetiology remain largely unknown. Awareness amongst health professionals is important to limit morbidity and avoid unnecessary periods of untreated hypothyroidism. PMID: 32264785 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Conclusion: Malignancy-associated hyperthyroidism has a similar underlying mechanism to subacute thyroiditis, in so much as there is damage or destruction of thyroid tissue. In cases of subacute thyroiditis this damage is self-limited, and there is recovery of thyroid function. In some cases of thyroiditis associated with malignancy there may be thyroid gland recovery as the underlying malignancy is treated and controlled. However, if the malignancy progresses, eventual hypothyroidism is likely to ensue. PMID: 32154117 [PubMed]
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Transl Endocrinol Source Type: research
ConclusionsEarly radioiodine treatment will potentially reduce mortality and should be offered to patients with severe disease. However, thionamides are still suitable for patients with milder disease, contraindications to radioiodine, or individuals who choose to avoid permanent hypothyroidism. Ultimately, a patient individualised approach that prioritises early and  sustained control of hyperthyroidism will improve long-term outcomes regardless of the therapy modality used.
Source: Thyroid Research - Category: Endocrinology Source Type: research
ConclusionMalignancy-associated hyperthyroidism has a similar underlying mechanism to subacute thyroiditis, in so much as there is damage or destruction of thyroid tissue. In cases of subacute thyroiditis this damage is self-limited, and there is recovery of thyroid function. In some cases of thyroiditis associated with malignancy there may be thyroid gland recovery as the underlying malignancy is treated and controlled. However, if the malignancy progresses, eventual hypothyroidism is likely to ensue.
Source: Journal of Clinical and Translational Endocrinology - Category: Endocrinology Source Type: research
Imaging tests of the neck assist in the diagnosis and management of thyroid conditions including thyroid cancer. Ultrasound (US) is usually the first imaging test used. For nodules in the neck, US is usually appropriate to determine cancer risk. CT with or  without intravenous (IV) contrast may also be appropriate. For suspected enlarged thyroid (goiter), US or CT without IV contrast is usually appropriate. CT with IV contrast, MRI, or nuclear medicine scan may also be appropriate. If overactive thyroid (hyperthyroidism) or excessive thyr oid hormone (thyroto...
Source: Journal of the American College of Radiology : JACR - Category: Radiology Authors: Tags: Appropriate use criteria Source Type: research
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