Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience

Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In Childhood (INFORM) registry study offers comprehensive molecular profiling of high-risk tumours to identify target  alterations for potential precision therapy. We analysed molecular characteristics and clinical data after brainstem biopsy of all enrolled newly diagnosed DIPGs.

Source: European Journal of Cancer - April 21, 2019 Category: Cancer & Oncology Authors: Elke Pfaff, Ahmed El Damaty, Gnana Prakash Balasubramanian, Mirjam Blattner-Johnson, Barbara C. Worst, Sebastian Stark, Hendrik Witt, Kristian W. Pajtler, Cornelis M. van Tilburg, Ruth Witt, Till Milde, Martin Jakobs, Petra Fiesel, Michael C. Fr ühwald, Source Type: research