Acute Atomoxetine Selectively Modulates Encoding of Reward Value in Ventral Medial Prefrontal Cortex.

CONCLUSIONS: These results suggest that atomoxetine affects reward value encoding through selective modulation of vmPFC activity related to reward outcome. Therefore, such modulatory action may partly contribute to a therapeutic effect of atomoxetine for a group of ADHD patients with increased activity in vmPFC. PMID: 31130571 [PubMed - in process]
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research

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Publication date: Available online 12 November 2019Source: NeuroImageAuthor(s): Juha Salmi, Mostafa Metwaly, Jussi Tohka, Kimmo Alho, Sami Leppämäki, Pekka Tani, Anniina Koski, Tamara Vanderwal, Matti LaineAbstractIndividuals with attention-deficit/hyperactivity disorder (ADHD) have difficulties navigating dynamic everyday situations that contain multiple sensory inputs that need to either be attended to or ignored. As conventional experimental tasks lack this type of everyday complexity, we administered a film-based multi-talker condition with auditory distractors in the background. ADHD-related aberrant brain r...
Source: NeuroImage - Category: Neuroscience Source Type: research
While there are a number of drugs to treat Attention Deficit Hyperactivity Disorder (ADHD), they can have some pretty serious side effects. Researchers in Singapore at the country’s Institute of Mental Health (IMH), Duke-NUS (National Universit...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Pediatrics Psychiatry Source Type: blogs
Abstract Primary nocturnal enuresis (PNE) is always associated with attention impairment, some of which even could develop to attention deficit hyperactivity disorder. The mechanism of attention impairment is not clear, especially lacking of objective indicators of neuroimaging. The aim of this study is to explore the possible functional imaging mechanism of impaired attention in PNE children. A total of 26 PNE children and 26 age-matched normal controls were recruited. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on these children. Degree centrality (DC) of key brain regions of DAN ...
Source: International Journal of Developmental Neuroscience - Category: Neuroscience Authors: Tags: Int J Dev Neurosci Source Type: research
Many studies have shown abnormal functional connectivity in children with attention deficit hyperactivity disorder (ADHD) by using resting-state functional magnetic resonance imaging (rs-fMRI). However, few studies illustrated that to what extent these findings were consistent across different datasets. The present study aimed to assess the consistency of abnormal functional connectivity in children with ADHD across the four datasets from a public-assess rs-fMRI ADHD cohort, namely, ADHD-200. We employed the identical analysis process of previous studies and examined a few factors, including connectivity with the seed regi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSION: Cerebral functional connectivity at rest is lower in ADHD patients when compared with healthy controls, however, the difference was not statistically significant. PMID: 31563420 [PubMed - as supplied by publisher]
Source: Radiologia - Category: Radiology Authors: Tags: Radiologia Source Type: research
Introduction: After a traumatic event, children and adolescents may present several clinical consequences, the most common being Post-Traumatic Stress Disorder (PTSD). Most children and adolescents with PTSD have comorbid disorders, such Attention Deficit Hyperactivity Disorder, depression, attachment and anxiety disorders, sleep disturbances and behavior problems. However, epidemiological studies on the development of PTSD and other psychiatric disorders in children and adolescents as a consequence of a terrorist attack and mass murder are lacking. Long-term follow-up of exposed children and adolescents will help identify...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Probing the "Default Network Interference Hypothesis" With EEG: An RDoC Approach Focused on Attention. Clin EEG Neurosci. 2019 Jul 19;:1550059419864461 Authors: Gerrits B, Vollebregt MA, Olbrich S, van Dijk H, Palmer D, Gordon E, Pascual-Marqui R, Kessels RPC, Arns M Abstract Studies have shown that specific networks (default mode network [DMN] and task positive network [TPN]) activate in an anticorrelated manner when sustaining attention. Related EEG studies are scarce and often lack behavioral validation. We performed independent component analysis (ICA) across different frequencies (sourc...
Source: Clinical EEG and Neuroscience - Category: Neuroscience Authors: Tags: Clin EEG Neurosci Source Type: research
Authors: Tran K, Wu J Abstract A 2-year-old male pediatric patient experienced a partial occlusion of the internal carotid and subsequent asphyxiation resulting in hypoxic brain injury that was later misdiagnosed as primary attention deficient hyperactivity disorder (ADHD). Imaging analyses using diffusion tensor imaging (DTI), positron emission tomography (PET), and magnetic resonance imaging (MRI) quantitative volumetrics (QV) were used nine years following the incident to identify whether his development of ADHD is of a primary heritability or secondary hypoxic brain injury sequelae. The patient's DTI analysis g...
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
Publication date: September 2019Source: Research in Developmental Disabilities, Volume 92Author(s): Guillaume Pineau, Thomas Villemonteix, Hichem Slama, Martin Kavec, Danielle Balériaux, Thierry Metens, Simon Baijot, Alison Mary, Nicolas Ramoz, Philip Gorwood, Philippe Peigneux, Isabelle MassatAbstractDopamine active transporter gene (DAT1) is a candidate gene associated with attention-deficit/hyperactivity disorder (ADHD). The DAT1 variable number tandem repeat (VNTR)-3’ polymorphism is functional and 9R carriers have been shown to produce more DAT than 10R homozygotes. We used functional magnetic resonance i...
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Abstract The study aimed to investigate the pathologic mechanism of functional brain regions in attention-deficit hyperactivity disorder (ADHD) patients through making comparisons of normal and ADHD children from the perspective of the network nodes of brain network and the intensity of functional connection between bilateral of hemispheres by resting-state functional magnetic resonance imaging (fMRI). Thirty-five ADHD and forty-two children were examined by resting-state functional magnetic resonance imaging (fMRI) scans. Data analysis was done via the degree centrality (DC) and voxel-mirrored homotopic connectiv...
Source: International Journal of Developmental Neuroscience - Category: Neuroscience Authors: Tags: Int J Dev Neurosci Source Type: research
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