Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities.

In conclusion, based on our review we may posit that shared immune-inflammatory pathways and especially activated microglia underpin comorbid depression and CFS. As such, microglial activation and neuro-inflammation may be promising targets to treat the overlapping manifestations of both depression and CFS. PMID: 31136774 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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ConclusionsPA activates PXR signalling and suppresses NF-κB signalling, consequently causing ameliorating inflammation. Results highlight the importance of PXR–NF-κB crosstalk in colitis and suggest a novel therapeutic reagent.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS PVT1 exerts an oncogenic role through activating Wnt/ß-catenin signaling in pituitary adenoma cells. The present results may provide a potential therapeutic target or approach for treating pituitary adenomas. PMID: 31604907 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 10 October 2019Source: NeuroImageAuthor(s): Spurny B, Seiger R, Moser P, Vanicek T, M.B. Reed, Heckova E, Michenthaler P, Basaran A, Gryglewski G, Klöbl M, Trattnig S, Kasper S, Bogner W, Lanzenberger RAbstractNeural plasticity is a complex process dependent on neurochemical underpinnings. Next to the glutamatergic system which contributes to memory formation via long-term potentiation (LTP) and long-term depression (LTD), the main inhibitory neurotransmitter, GABA is crucially involved in neuroplastic processes. Hence, we investigated changes in glutamate and GABA levels in the brai...
Source: NeuroImage - Category: Neuroscience Source Type: research
Conclusions: TR2 had a positive effect on the office workers' energy expenditure, blood parameters, depression, fatigue, and productivity. PMID: 31603033 [PubMed - as supplied by publisher]
Source: International Journal of Occupational Safety and Ergonomics - Category: Occupational Health Tags: Int J Occup Saf Ergon Source Type: research
Conclusion: Previous suicide attempt, smoking, unemployment, and suffering from at least one mental disorder were the significant predictors of suicide death. Among mental disorders, major depressive disorder and substance use disorder were the most prevalent mental health problems. PMID: 31602433 [PubMed]
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Arch Acad Emerg Med Source Type: research
Publication date: Available online 12 October 2019Source: Physiology &BehaviorAuthor(s): Qingfeng Xiao, Ze Xiong, Chunan Yu, Jiafeng Zhou, Qichen Shen, Liangliang Wang, Xiaoxian Xie, Zhengwei FuAbstractDepression is the leading cause of mental health-related disease globally, and it affects an estimated 300 million people worldwide. However, its physiological causes are not fully understood. Since available antidepressants fail to achieve complete disease remission, treating diversification of depression may be a useful contribution. Crocin, one of the main glycosylated carotenoids of saffron, has been found to have nu...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Neurological insights into how the brain processes stress, and how it can develop into depression, have led to new interventionsIt ’s a damp, midweek afternoon. Even so, Cardiff’s walk-in stress management course has pulled in more than 50 people. There are teenagers, white-haired older people with walking aids, people from Caucasian, Asian and Middle Eastern backgrounds. There is at least one pair who look like a parent an d child – I’m unsure who is there to support whom.The course instructor makes it clear that she is not going to ask people to speak out about their own stress levels in this firs...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Neuroscience Depression Anxiety Mental health Society Psychology Cities Source Type: news
Zoe M. Tapp, Jonathan P. Godbout and Olga N. Kokiko-Cochran* Department of Neuroscience, Institute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, United States Each year approximately 1.7 million people sustain a traumatic brain injury (TBI) in the US alone. Associated with these head injuries is a high prevalence of neuropsychiatric symptoms including irritability, depression, and anxiety. Neuroinflammation, due in part to microglia, can worsen or even cause neuropsychiatric disorders after TBI. For example, mounting evidence demonstrates that microglia become &ld...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
DISCUSSION: Here, we propose strategies to recognize "leaky gut" in a clinical setting using the most adequate clinical chemistry and molecular immunology assays. PMID: 30430944 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Conclusions: Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between MDD and its medical comorbidities. This emerging literature opens relevant preventative and therapeutic perspectives.Psychother Psychosom 2017;86:31-46
Source: Psychotherapy and Psychosomatics - Category: Psychiatry & Psychology Source Type: research
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