Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities.

In conclusion, based on our review we may posit that shared immune-inflammatory pathways and especially activated microglia underpin comorbid depression and CFS. As such, microglial activation and neuro-inflammation may be promising targets to treat the overlapping manifestations of both depression and CFS. PMID: 31136774 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31136774?dopt=Abstract

Source: Behavioural Brain Research - May 24, 2019 Category: Neurology Authors: Filho AJMC, Macedo DS, de Lucena DF, Maes M Tags: Behav Brain Res Source Type: research