Molecules, Vol. 24, Pages 2005: The Up-Regulation of Oxidative Stress as a Potential Mechanism of Novel MAO-B Inhibitors for Glioblastoma Treatment

This study demonstrated that our novel MAO-B inhibitors increase the oxidative stress level resulting in a cell cycle arrest and markedly reduces glioma cells migration thus reinforcing the hypothesis of a critical role-played by MAO-B in mediating oncogenesis in high-grade gliomas.

Source: Molecules - May 24, 2019 Category: Chemistry Authors: Guya Diletta Marconi Marialucia Gallorini Simone Carradori Paolo Guglielmi Amelia Cataldi Susi Zara Tags: Article Source Type: research