Effects of prenatal exposure to chrysotile asbestos on hippocampal neurogenesis and long-term behavioral changes in adult male rat offspring.

In this study, twenty-eight pregnant Wistar rats were divided into four groups and received three-times repeated intraperitoneal injections of normal saline, chrysotile, ascorbic acid and the combination of chrysotile and ascorbic acid on gestational days 11, 14 and 17. The maternal serum levels of malondialdehyde (MDA) and prooxidant-antioxidant balance (PAB) and hippocampal MDA content in adult male offspring were measured. At postnatal day (PND) 60, elevated plus maze was performed to determine anxiety-like behavior, also depression-like behavior was examined using a forced swim test at PND 61- 62. Thereafter, the percentage of Ki-67, NeuN and GFAP positive cells in the hippocampal dentate gyrus were studied by immunostaining. Our data showed that prenatal exposure to chrysotile increased the maternal serum level of MDA and PAB as well as hippocampal MDA content in adult male offspring, also increased the depression- and anxiety-like behaviors of adult male offspring and decreased the hippocampal Ki-67+, NeuN+ and GFAP+ cells in dantate gyrus of adult male offspring. However, co-administration of ascorbic acid and chrysotile decreased hippocampal lipid peroxidation and increased the Ki-67+, NeuN+ and GFAP+ cells in adult male offspring. In summary, these results indicated that oxidative stress induced by prenatal exposure to chrysotile, lead to the long-lasting decrease of the hippocampal cell proliferation and neuronal differentiation as well as astrogliosis of adult male...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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ConclusionsALS8 patients present mild executive dysfunction and behavioural changes such as mood disorders, apathy and stereotypic behaviour. Our findings suggest that ALS8 is not a pure motor disorder and it is associated with subtle cognitive and behavioural impairments.
Source: Journal of Neurology - Category: Neurology Source Type: research
CONCLUSIONS: Contrary to earlier reports of lower-quality care, patients with and without mental illness had similar preventive and chronic disease management care quality following medical home implementation. PMID: 31310189 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
In this study, we aimed to evaluate the effects of pregnancy on the serum level of HE4. Forty-six singleton pregnant women in the study group and 40 premenopausal women in the control group were included. HE4 and Ca125 levels were measured longitudinally at each trimester of pregnancy in the study group and once in the control group at the recruitment. In total 46, 38 and 33 pregnant patients blood samples were analysed in the first, second and third trimester of pregnancy, respectively. The analysis was performed in 31 of the pregnant patients (31/46, 67.4%) in each trimester of pregnancy. A comparison of the median HE4 l...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
We describe the implementation, clinical outcomes and participant perspectives for e-Healthystrides©. Setting: Three independent ambulatory clinics and an historic African American (AA) church. Participants: Adults with diagnosed diabetes mellitus type 2. Intervention: e-Healthystrides© health coach facilitated intervention. Primary outcome: Acquisition of three new self-management behaviors. Secondary outcomes: Blood pressure, blood glucose, A1c, attrition rate and participant perspectives of e-Healthystrides©. Methods: A convergent parallel mixed method design was used in both pilot...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
Publication date: November 2019Source: Food Research International, Volume 125Author(s): Francisco Allan L. de Carvalho, Jose M. Lorenzo, Mirian Pateiro, Roberto Bermúdez, Laura Purriños, Marco Antonio TrindadeAbstractThe effects of guarana seed and pitanga leaf extracts on the physical–chemical and sensory characteristics, and oxidative stability of modified atmosphere-packaged lamb patties with fat replacement during storage (2 °C) were investigated. Four treatments were prepared: control (without antioxidant); with BHT (10 mg/kg); with 250 mg/kg guarana extract (G250); with 250 mg/kg pita...
Source: Food Research International - Category: Food Science Source Type: research
The objective of this study was to characterize the physicochemical and antioxidant properties of black bean protein, hydrolyzed by ficin, bromelain or alcalase until 300 min of hydrolysis. Results showed that bromelain and alcalase hydrolysates possessed higher degree of hydrolysis (DH) than that of ficin, thereby presenting different ultraviolet absorption, fluorescence intensity and circular dichroism. Moreover, all hydrolysates possessed the capacity to scavenge DPPH radical with the lowest IC50 of 21.11 μg/mL, as well as to chelate ferrous ion (Fe2+) with the IC50 values ranging from 6.82 to 30.68 μg/mL. I...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
Publication date: Available online 16 July 2019Source: Food ChemistryAuthor(s): Abhishek Shukla, R.S. Shukla, Chandan Das, Vaibhav V. GoudAbstractPresence of pungent gingerols in ginger oleoresin makes it an ideal natural flavoring candidate for the food industry. The study reports its incorporation for synergistic enhancement of flavor and nutraceutical portfolio of candied mango. The process is systematically optimized at bench-scale for gingerols infusion and subsequent candying treatment in a range of hypo and hypertonic osmotic solutions for critical transport properties. After that, optimization of the drying process...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 16 July 2019Source: Food BioscienceAuthor(s): Mayara Schulz, Josiane Freitas ChimAbstractRubus L. (Rosaceae) berries have received worldwide attention, mainly for their nutritional and bioactive value. The raspberries and blackberries of this genus contain nutrients and bioactive compounds such as vitamins, minerals, proteins, sugars, and polyphenols. This review summarizes available data on the physical-chemical characteristics, nutritional composition, biologically active compounds, and biological activities of Rubus raspberries (Rubus idaeus L., R. ellipticus Smith, R. niveus Thunb., R...
Source: Food Bioscience - Category: Food Science Source Type: research
In response to my note yesterday about direct-access-testing (DAT) (see:New Definition for DTC Lab Testing Prompted by EverlyWell Business Model), Andrea Pitkin, Ph.D., commented in the form of a presentation she had made at the last ASCLS annual meeting. She makes a number of important observations that I hope to comment on in upcoming days. For this note, I will address the following point copied from her comment:How are consumer testing and Patient Generated Health Data (PGHD) integrated and used within the medical record?Some apps allow upload to the physician's EHR. They should not be comingled with labo...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Clinical Lab Testing Diagnostics Direct Access Testing (DAT) Electronic Health Record (EHR) Health Wearable Healthcare Information Technology Lab Industry Trends Lab Standards Medical Consumerism Point-of-Care Testing Public Health R Source Type: blogs
Authors: Auger N, Low N, Carrier FM, Ayoub A, Luu TM Abstract BACKGROUND: Neonatal abstinence syndrome is increasingly prevalent, and may be related to opioid use disorders caused by postoperative prescriptions for pain control. We assessed the association of maternal prepregnancy surgery with risk of neonatal abstinence syndrome from opioid use disorders in future pregnancies. METHODS: We conducted a longitudinal retrospective cohort study of 2 182 365 deliveries in Quebec, Canada, between 1989 and 2016. The main exposure was maternal prepregnancy surgery. The main outcome measure was neonatal abstinence syndr...
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
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