Association of Childhood Abuse with Incident Systemic Lupus Erythematosus in Adulthood in a Longitudinal Cohort of Women.

We examined if childhood abuse was associated with heightened risk of incident systemic lupus erythematosus (SLE). METHODS: Data were from the Nurses' Health Study II, a cohort of U.S. female nurses enrolled in 1989, followed with biennial questionnaires. We measured childhood physical and emotional abuse with the Physical and Emotional Abuse Subscale of the Childhood Trauma Questionnaire and sexual abuse with the Sexual Maltreatment Scale of the Parent-Child Conflict Tactics Scale, both administered in 2001. We identified incident SLE (>4 American College of Rheumatology 1997 classification criteria) through 2015. We used multivariable Cox regression models to evaluate the association between childhood abuse and SLE accounting for potential confounders (e.g. parental education, occupation, home ownership) and mediators (e.g. depression, posttraumatic stress disorder (PTSD)). RESULTS: Among 67,516 women, there were 94 incident SLE cases. In adjusted models, exposure to the highest vs. lowest physical and emotional abuse was associated with 2.57 times greater risk of SLE (95% CI 1.30-5.12). We found that 17% (p
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research

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ConclusionLong-term Abatacept therapy is effective in the majority of patients with LRBA deficiency.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 24 June 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Xinyu Fang, Yan Chen, Yewei Wang, Juanjuan Ren, Chen ZhangAbstractObjectivesDepressive symptoms are commonly seen in schizophrenia. Increasing evidence implicates that both SIRT1 and BDNF closely related to the development of depression. So we here aimed to explore the effect of BDNF and SIRT1 on the depressive symptoms, and also explore the hazard factors for the depression in schizophrenia.MethodsA group of 203 participants (case/controls, 174/29) was recruited in the present work. Significant d...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
ConclusionReassurance seeking appears to be a common factor across anxiety disorders though the themes of the reassurance may differ. Further, reduction in excessive reassurance seeking may be an important component in treatment outcome.
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
Publication date: Available online 22 June 2019Source: Neuroscience LettersAuthor(s): Nastaran Rahimi, Mahsa Hassanipour, Fatemeh Yarmohammadi, Hedyeh Faghir-Ghanesefat, Nastaran Pourshadi, Erfan Bahramnejad, Ahmadreza DehpourAbstractThe neuro-protective effects of rubidium and lithium as alkali metals have been reported for different central nervous system dysfunctions including mania and depression. The aim of this study was evaluating as well as comparing the effects of rubidium chloride (RbCl) and lithium chloride (LiCl) on different seizures paradigms in mice and determining the involvement of NMDA receptors and nitre...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Mental health and well - being of older adults should be addressed in these settings, authors say
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Geriatrics, Internal Medicine, Nursing, Psychiatry, Journal, Source Type: news
ConclusionsThis study indicates that there was no significant correlation between IgG antibodies against Toxocara and variables such as gender and age. Based on the statistical analysis, there was no significant difference in Toxocara seropositivity between our control population with MS and RA patients.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
BACKGROUND: Brief psychosocial intervention (BPI) is a treatment for adolescent depression that has recently demonstrated clinical effectiveness in a controlled trial. The aim of this study is to explore experiences of adolescents with major depression rec...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Suicide is still the leading cause of death in the 15 to 34-year age group, especially for girls aging 15 to 19-year old. In China particularly, the suicide rate of female is 60% higher than male. The gender difference on suicidal ideation and ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
I was greatly saddened to hear the news of a young resident, Dr Payal Tadvi, committing suicide at the BYL Nair Hospital and Topiwala Medical College in Mumbai. However, it is heartening to see that some fellow students, her family and the Tadvi Bhil commu...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
We examined depression and anxiety symptom trajectories in Mexican-origin youth (N =  674) and tested longitudinal associations with acculturation dimensions. We used eight waves of data from the California Families Project, collected annually from ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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