National, regional, and state-level burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in India: modelled estimates for 2000–15

Publication date: June 2019Source: The Lancet Global Health, Volume 7, Issue 6Author(s): Brian Wahl, Apoorva Sharan, Maria Deloria Knoll, Rajesh Kumar, Li Liu, Yue Chu, David A McAllister, Harish Nair, Harry Campbell, Igor Rudan, Usha Ram, Molly Sauer, Anita Shet, Robert Black, Mathuram Santosham, Katherine L O'Brien, Narendra K AroraSummaryBackgroundIndia accounts for a disproportionate burden of global childhood illnesses. To inform policies and measure progress towards achieving child health targets, we estimated the annual national and state-specific childhood mortality and morbidity attributable to Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) between 2000 and 2015.MethodsIn this modelling study, we used vaccine clinical trial data to estimate the proportion of pneumonia deaths attributable to pneumococcus and Hib. The proportion of meningitis deaths attributable to each pathogen was derived from pathogen-specific meningitis case fatality and bacterial meningitis case data from surveillance studies. We applied these proportions to modelled state-specific pneumonia and meningitis deaths from 2000 to 2015 prepared by the WHO Maternal and Child Epidemiology Estimation collaboration (WHO/MCEE) on the basis of verbal autopsy studies from India. The burden of clinical and severe pneumonia cases attributable to pneumococcus and Hib was ascertained with vaccine clinical trial data and state-specific all-cause pneumonia case estimates prepared by WHO/MCEE by us...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research