Celecoxib modifies glomerular basement membrane, mesangium and podocytes in OVE26 mice, but ibuprofen is more detrimental.

This study substantiates the need to more closely consider COX-2 selective inhibitors like Celecoxib as alternatives to non-selective NSAIDs for therapeutic management in a setting of chronic kidney disease.

Source: Clinical Science - January 11, 2013 Category: Biomedical Science Authors: R Nasrallah, S J Robertson, J Karsh, R L Hebert Source Type: research