Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury

Conclusion
In the present study, we show that the deletion of the ageing gene p66Shc protects mice from ischaemia/reperfusion brain injury through a blunted production of free radicals. The ROS mediator p66Shc may represent a novel therapeutical target for the treatment of ischaemic stroke.

Source: European Heart Journal - January 6, 2013 Category: Cardiology Authors: Spescha, R. D., Shi, Y., Wegener, S., Keller, S., Weber, B., Wyss, M. M., Lauinger, N., Tabatabai, G., Paneni, F., Cosentino, F., Hock, C., Weller, M., Nitsch, R. M., Luscher, T. F., Camici, G. G. Tags: FASTTRACK BASIC SCIENCE Source Type: research