Hope for those with Huntington's – podcast

Robin McKie, the Observer ’s science and environment editor, discusses an innovative drug that may soon offer ways to fight Huntington’s disease, while Mark Newnham describes being diagnosed with the inherited condition. Plus: Peter Beaumont describes his trip to the Costa Rican cloud forest, at threat from climate chang eForMark Newnham and thousands of others who havebeen told they have inherited Huntington ’s disease, the future would appear bleak, a prospect of inexorable physical and mental decline. But scientists believe they areclosing in on a treatment to control its worst effects.Anushka Asthana talks toRobin McKie, the Observer ’s science and environment editor, who tells her about the testing of a new drug, RG6042, that appears to reduce levels of a toxic protein that builds up in brain cells and is believed to trigger the disease. She also talks to Newnham, 32, who has tested positive for the gene.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Huntington's disease Science Climate change Costa Rica Medical research Source Type: news

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EU-funded researchers have developed innovative genetic reprogramming techniques to replace and repair brain cells, opening up novel therapeutic pathways to combat debilitating disorders such as Parkinson's and Huntington's disease.
Source: EUROPA - Research Information Centre - Category: Research Source Type: news
(University of Barcelona) An article published in the Journal of Medicinal Chemistry shows a new family of molecules with high affinity to join imidazoline receptors, which are altered in the brain of those patients with neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's. According to the preclinical study, the merge of these specific ligands to I2 receptors improves cognitive skills and some biomarkers which are indicators of brain neurodegenerative processes in murine models.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ie Lei Wang Neuro-degenerative disease is a common progressive nervous system disorder that leads to serious clinical consequences. Gait rhythm dynamics analysis is essential for evaluating clinical states and improving quality of life for neuro-degenerative patients. The magnitude of stride-to-stride fluctuations and corresponding changes over time—gait dynamics—reflects the physiology of gait, in quantifying the pathologic alterations in the locomotor control system of health subjects and patients with neuro-degenerative diseases. Motivated by algebra topology theory, a topological data analysis...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
CONCLUSIONS: Sexual disorders in HD are common. This is a problem that is probably underestimated, both by patients/caregivers and physicians, who should focus more on these symptoms in order to improve patient quality of life. PMID: 32242915 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Tags: Neurol Neurochir Pol Source Type: research
Huntington ’s disease (HD) is a dominantly inherited neurodegenerative disorder that affects cognitive and motor abilities by primarily targeting the striatum and cerebral cortex. HD is caused by a mutation elo...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
Abstract As the population ages, the incidence and prevalence of neurodegenerative disorders will continue to increase. Persons with neurodegenerative disease frequently experience sleep disorders, which not only affect quality of life, but potentially accelerate progression of the disease. Unfortunately, pharmacological interventions are often futile or have adverse effects. Therefore, investigation of non-pharmacological interventions has the potential to expand the treatment landscape for these disorders. The last decade has observed increasing recognition of the beneficial role of exercise in brain diseases, a...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
Abstract Several epidemiological studies support low cancer rates in patients with neurodegenerative disorders, including Parkinson's disease, Huntington's disease, and Alzheimer's disease. Different mechanisms were raised as possible causes, from mutated tumor suppressor genes (PARKIN, PINK1) to small interfering RNA based on the CAG trinucleotide repeat expansions located in introns or untranslated regions. However, as every rule has an exception, some tumors have an increased incidence in these neurodegenerative diseases such as breast and skin cancer (melanoma). This mini-review aims to establish the epidemiol...
Source: Journal of Integrative Neuroscience - Category: Neuroscience Authors: Tags: J Integr Neurosci Source Type: research
CONCLUSIONS DEGs, including SORT1, CRYAB, PSMA1, and SDHA may have roles in the pathogenesis of PD through the MAPK, Wnt, and Notch signaling pathways. PMID: 32210219 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Huntington ’s disease (HD) is caused by the expression of a mutated variant of Huntingtin (mHtt), which results in the complex pathology characterized by a defective function of the nervous system and altered i...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
The original version of this article unfortunately contained a mistake. The name of one author is not presented correctly in the author group.
Source: Journal of Neurology - Category: Neurology Source Type: research
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