Risks and benefits of corticosteroids in arthritic diseases in the clinic.

Risks and benefits of corticosteroids in arthritic diseases in the clinic.
Biochem Pharmacol. 2019 Apr 09;:
Authors: Petta I, Peene I, Elewaut D, Vereecke L, De Bosscher K
Abstract
Glucocorticoids (GCs) constitute a first line treatment for many autoimmune and inflammatory diseases. Due to their potent anti-inflammatory and immunosuppressive actions, GCs are added frequently to disease modifying antirheumatic drugs (DMARDs) in various arthritic diseases, such as rheumatoid arthritis. However, their prolonged administration or administration at high doses is associated with adverse effects that may be (quality of) life-threatening, including osteoporosis, metabolic, gastrointestinal and cardiovascular side effects. In this review, we summarize the clinical and pharmacological effects of GCs in different arthritic diseases, while documenting the current research efforts towards the identification of novel and more efficient GCs with reduced side effects.
PMID: 30978323 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Authors: Petta I, Peene I, Elewaut D, Vereecke L, De Bosscher K Tags: Biochem Pharmacol Source Type: research