ABC transporters in neurological disorders: an important gateway for botanical compounds mediated neuro-therapeutics.

ABC transporters in neurological disorders: an important gateway for botanical compounds mediated neuro-therapeutics. Curr Top Med Chem. 2019 Apr 12;: Authors: Jha NK, Kar R, Niranjan R Abstract Neurodegeneration is a distinguishing feature of many age related disorders. There are a number of factors that can modulate the pathology of these disorders. ATP-binding cassette (ABC) transporters are primarily involved in the maintenance of normal brain homeostasis by eliminating toxic peptides and compounds from the brain. Also, ABC transporters protect the brain from the unwanted effects of endogenous and exogenous toxins that can enter the brain parenchyma. Therefore, these transporters have the ability to determine the pathological outcomes of several neurological disorders. For instance, ABC transporters like P-glycoprotein (ABCB1), and BCRP (ABCG2) have been reported to facilitate the clearance of peptides such as amyloid-β (Aβ) that accumulate in the brain during Alzheimer's disease (AD) progression. Other members such as ABCA1, ABCA2, ABCC8, ABCC9, ABCG1 and ABCG4 also have been reported to be involved in the progression of various brain metabolic disorders such as HIV-associated dementia, Multiple sclerosis (MS), Ischemic stroke, and Epilepsy. However, these defective transporters can be targeted by numerous botanical compounds such as Verapamil, Berberine and Fascalpsynas a therapeutic target to treat these neurological outcome...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research