Prenatal Exposure to Di-(2-ethylhexyl) Phthalate and High-fat Diet Synergistically Disrupts Mouse Fetal Oogenesis and Affects Folliculogenesis.

In this study, our goal was to determine if there are synergistic effects of DEHP exposure at an environmentally relevant level (20 μg/kg body weight/day) and high-fat diet on oogenesis and folliculogenesis. Dams were fed with a high-fat diet (45 kcal% fat) or a control diet (10 kcal% fat) one week before mating and during pregnancy and lactation. The pregnant mice were dosed with DEHP (20 μg/kg body weight/day) or vehicle control from E10.5 to litter birth. We discovered that treatment with an environmentally relevant dosage of DEHP and consumption of high-fat diet significantly increases synapsis defects in meiosis and affects folliculogenesis in the F1 generation. PMID: 30939196 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30939196?dopt=Abstract

Source: Biology of Reproduction - April 1, 2019 Category: Reproduction Medicine Authors: Mirihagalle S, You T, Suh L, Patel C, Gao L, Rattan S, Qiao H Tags: Biol Reprod Source Type: research